选择性CDK4/6抑制剂在实体肿瘤治疗中的应用

Application of selective CDK4/6 inhibitors in solid cancers therapy

选择性细胞周期素依赖激酶(CDK)抑制剂已用于ER^+/HER2^-晚期乳腺癌的治疗,在其他实体肿瘤的临床前研究和临床研究也正在进行中.CDK4/6抑制剂在实体肿瘤中显示出良好疗效,未来CDK4/6抑制剂发展的方向是寻找预测标志物、克服耐药和探索联合治疗模式.

Cyclin-dependent kinase (CDK) inhibitors have been approved for the treatment of ER +/HER2-advanced breast cancer,and preclinical study and clinical trials are under way for multiple solid cancers.CDK4/6 inhibitors have shown good efficacy for human solid cancers,and it's future development direction are biomarkers,drug resistance and combined therapy in the future.