凉血清热法联合盐酸普罗帕酮治疗气阴两虚型阵发性房颤临床研究

Clinical Study of Cooling Blood and Clearing Heat Method Combined with Propafenone Hydrochlorideon for Treatment of Paroxysmal Atrial Fibrillation of QI and Yin Deficiency Syndrome

目的:研究凉血清热法联合盐酸普罗帕酮治疗气阴两虚型阵发性房颤的疗效。方法:90例气阴两虚型阵发性房颤患者随机分为观察组和对照组各45例。观察组给予凉血清热汤剂联合盐酸普罗帕酮治疗,对照组给予单纯盐酸普罗帕酮治疗。比较两组整体疗效和治疗前后房颤发作情况,记录最大P波时限(Pmax)、最小P波时限(Pmin)、P波离散度(Pdis)及平均心率等心电图指标的变化。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。两组治疗后房颤发作次数和持续时间较治疗前均减少,差异有统计学意义(P<0.05);治疗后,观察组房颤发作次数和持续时间均少于对照组,差异有统计学意义(P<0.05)。两组治疗后Pmax、Pdis及平均心率较治疗前均显著降低,差异有统计学意义(P<0.05);治疗后,观察组Pmax、Pdis及平均心率均显著低于对照组,差异有统计学意义(P<0.05)。结论:凉血清热法联合盐酸普罗帕酮治疗气阴两虚型阵发性房颤疗效显著,有助于改善患者的临床症状和心电图表现。

Objective:To study the effect of cooling blood and clearing heat method combined with propafenone hydrochloride on paroxysmal atrial fibrillation of qi and yin deficiency syndrome. Methods:A total of 90 patients with paroxysmal atrial fibrillation of qi and yin deficiency syndrome were divided into observation group and control group randomly,with 45 cases in each group. The observation group was treated with cooling blood and clearing heat decocttion combined with propafenone hydrochloride,while the control group was only treated with propafenone hydrochloride. The curative effect and atrial fibrillation of the two groups were compared before and after treatment. The changes of electrocardiogram parameters such as maximum P wave time limit(Pmax),minimum P wave time limit(Pmin),P wave dispersion(Pdis) and the average heart rate of the two groups were recorded. Results:The total effective rate of the observation group was higher than that of the control group and the difference was statistically significant(P<0.05). After treatment,the frequency and duration of atrial fibrillation in the two groups were less than those before treatment and the differences were statistically significant(P<0.05). The frequency and duration of atrial fibrillation in the observation group after treatment were less than those in the control group and the differences were statistically significant(P<0.05). After treatment,the Pmax,Pdisand average heart rate of the two groups were lower than those before treatment and the differences were statistically significant(P<0.05). The Pmax,Pdisand average heart rate in the observation group after treatment were lower than those in the control group and the differences were statistically significant(P<0.05). Conclusion:The cooling blood and clearing heat method combined with propafenone hydrochloride is effective in the treatment of paroxysmal atrial fibrillation of qi and yin deficiency syndrome,which is helpful to improve the clinical symptoms and electrocardiogram manifestation of the patients.