术前γ-谷氨酰转肽酶与淋巴细胞计数比值在肝细胞癌患者预后的意义

The significance of preoperative γ-glutamyl transpeptidase/lymphocyte count ratio in the prognosis of patients with small hepatocellular carcinoma

目的:探讨术前γ-谷氨酰转肽酶/淋巴细胞计数比值(GLR)在肿瘤直径小于5 cm肝细胞癌(肝癌)中预后的预测价值。方法:对216例肿瘤直径小于5 cm根治性手术患者进行分析。分析了肝癌与GLR、甲胎蛋白(AFP)的关系,采用单因素和多因素分析预测患者生存预后的危险因素。结果:GLR与性别、BCLC分期、微血管侵犯、早期复发有相关性。高GLR值对肝癌患者的整体生存率和无进展生存期均有影响,肿瘤大小与肝癌患者的预后密切相关。结论:GLR可作为肝癌根治术后单纯肿瘤直径≤5 cm患者动态监测预后的指标。

Objective: To explore the predictive value of preoperative γ-glutamyl transpeptidase/lymphocyte count ratio(GLR)in hepatocellular carcinoma(HCC)with tumor diameter≤5 cm. Methods: Retrospective analysis of 216 patients with tumor diameter(TS)≤5 cm radical operation were carried out. The relationship between HCC(HCC)and GLR, alpha-fetoprotein(AFP)was analyzed. Univariate and multivariate analysis was used to predict the risk factors of survival and prognosis. Results: GLR was correlated with sex, BCLC staging, microvascular invasion and early recurrence. High GLR value had effect on the overall survival rate and progression free survival of patients with HCC, and the tumor size was closely related to the prognosis of patients with small HCC. Conclusion: GLR can be used as a prognostic index in patients with simple tumor diameter≤5 cm after radical resection of liver cancer.