尿激酶联合低分子肝素与血栓通治疗脑梗死的临床效果观察

Clinical observation of urokinase combined with low molecular weight heparin and Xueshuantong in treating cerebral infarction

目的:探讨尿激酶联合低分子肝素与血栓通治疗脑梗死的临床效果。方法:选取脑梗死患者86例,以随机数字表法分为两组,对照组与观察组均为43例。两组患者入院后均提供常规治疗,对照组采用血栓通治疗,观察组在此基础上加入低分子肝素与尿激酶治疗。比较两组患者神经功能、日常生活能力及氧化应激指标。结果:与对照组比较,观察组治疗后NIHSS评分较低,Barthel指数较高,治疗后MDA、8-OHdG水平较低,SOD水平较高,差异有统计学意义(P<0.05)。结论:低分子肝素、尿激酶与血栓通联合用于脑梗死治疗对神经功能、氧化应激指标具有显著改善作用,可提高患者日常生活能力。

Objective:To explore the clinical effects of urokinase combined with low molecular weight heparin and Xueshuantong in the treatment of cerebral infarction. Methods: 86 patients with cerebral infarction were enrolled. The patients were divided into two groups by random number table method, and 43 cases in the control group and 43 in the observation group. Both groups received routine treatment after admission. The control group was treated with Xueshuantong. The observation group was treated with low molecular weight heparin, urokinase and Xueshuantong. The neurological function, daily living ability and oxidative stress index were compared between the two groups. Results:Compared with the control group, the NIHSS score was lower in the observation group, the Barthel index was higher, the MDA and 8-OHdG level was lower after treatment, and the SOD levels were higher, the difference was statistically significant(P<0.05). Conclusion:The combination of low molecular weight heparin, urokinase and Xueshuantong in the treatment of cerebral infarction can significantly improve the neurological function and oxidative stress index, and improve the daily living ability of patients.