白藜芦醇调控胃癌发生研究进展

Research Advances on Resveratrol in Prevention and Treatment of Gastric Cancer

胃癌(Gastric cancer)是一种起源于胃黏膜上皮的恶性肿瘤,也是世界上常见的几种癌症之一。亚洲尤其是中国是胃癌的高发区,中国每年的胃癌患病率和死亡率均高于世界平均水平。尽管个性化预防和治疗可降低患者死亡率,但幽门螺杆菌基因型、宿主基因多态性、癌细胞耐药性等诸多因素使得药物预防和治疗效果不明显。白藜芦醇(Resveratrol,Res)是一种广泛存在于植物中的二苯乙烯类化合物,具有抗肿瘤、抗氧化、抗炎、防治心血管疾病、抗真菌、延年益寿等多种药理学功效,尤其对肝癌、结肠癌、肺癌等癌症具有很好的治疗效果,但其在胃癌的特异性靶点、药物和发生通路等方面的研究较少,文章就白藜芦醇在胃癌防治方面的最新研究成果进行总结,将为胃癌药物研发提供新靶点和思路。

Gastric cancer is the malignant tumor originated from the epithelium of stomach,and also one of the most lethal cancers in the world. Asia,especially China,is a prevalent area of gastric cancer. The annual morbidity and mortality of gastric cancer in China is higher than the world average level. Although individualized prophylaxis and treatment can reduce the mortality rate,factors including the genotype of Helicobacter pylori,host gene polymorphism and drug resistance of cancer cell make the effect of drug prevention and treatment unobvious. Resveratrol( Res) is a stilbene compound which widely exists in plants. It possesses plenty of pharmacological effects including anti-tumor,anti-oxidation,anti-inflammatory,prevention and treatment in cardiovascular diseases,anti-fungal,and longevity enhancement. Although Res has good therapeutic effects on liver cancer,colon cancer and lung cancer,few pharmacological researches in gastric cancer have carried out it respect to the specific targets,drug interactions and anti-tumor pathways. This article has summarized the latest research results of Resin the prevention and treatment of gastric cancer,wishing to provide some new targets and ideas for drug research and development.