比较两种不同免疫方法检测乙型肝炎病毒感染血清学标志物的临床效果

Comparison of the Clinical Effects of two Different Immunological Methods for Detecting Serological Markers of Hepatitis B Virus Infection

目的探讨两种不同免疫方法检测乙型肝炎病毒感染血清学标志物的临床效果。方法于本院2017年6月至2018年6月接收的乙型肝炎病毒感染患者中选取1896例,随机分为观察组(948例)与对照组(948例)。观察组给予电化学发光法检测,对照组给予酶联免疫吸附法检测。对比两组患者检测到的血清学标志物阳性率情况以及两种检测方法诊断准确率情况。结果观察组HBeAb、HBeAg、HBcAb、HBsAb、HBsAg阳性检出率均高于对照组;观察组诊断准确率高于对照组。P<0.05,均有统计学意义。结论乙型肝炎病毒感染患者接受电化学发光法检测准确率更高,可准确诊断疾病并监测病情,临床实用价值较高,可推广。

Objective To investigate the clinical effects of two different immunological methods for detecting serological markers of hepatitis B virus infection. Methods A total of 1896 patients with hepatitis B virus infection received from June 2017 to June 2018 were randomly divided into observation group (948 cases) and control group (948 cases). The observation group was detected by electrochemiluminescence, and the control group was detected by enzyme-linked immunosorbent assay. The positive rate of serological markers detected in the two groups and the diagnostic accuracy of the two methods were compared. Results The positive detection rates of HBeAb, HBeAg, HBcAb, HBsAb and HBsAg in the observation group were higher than those in the control group. The diagnostic accuracy of the observation group was higher than that of the control group. P<0.05, both were statistically significant. Conclusion Patients with hepatitis B virus infection have higher accuracy in electrochemiluminescence detection, can accurately diagnose diseases and monitor the disease, and have high clinical value and can be promoted.