幽门螺杆菌致病因子研究新进展

Research progress on pathogenic mechanism of Helicobacter pylori

幽门螺杆菌(Helicobacter pylori,Hp)是胃癌、胃炎、胃溃疡等胃肠道疾病的首要致病因素,其致病机制的研究一直是焦点。既往研究已发现了空泡毒素A(vacuolating cytotoxin A,VacA)、细胞毒素相关蛋白A(cytotoxin-associated protein A,CagA)、脲酶(Urease)等致病因子所扮演的角色,但仍存不足。近年来一些新毒力因子及机制被陆续报道,如鞭毛、HtrA蛋白酶、脂多糖(lipopolysaccharide,LPS)、粘附素BabA及其介导的胃酸趋避、免疫逃逸、入侵干细胞的致病机制等,在此作一综述以供参考。

Helicobacter pylori(Hp)is considered to be the most important pathogenic factor associated with gastric cancer gastritis,peptic ulcer,and other gastrointestinal diseases.The study of pathogenic mechanism has always been the focus.The past researches have revealed some virulence factors such as vacuolating cytotoxin A(VacA),cytotoxin-associated protein A(CagA),Urease,etc.But these reveals of pathogenic mechanisms are still insufficient.Recently,some new virulence factors and mechanisms were have been reported,such as Hp flagllum,HtrA,lipopolysaccharide LPS,adhesion protein BabA,and the mechanism of avoiding stomach acid,escaping innate immunity,invading stem cells,etc.Here,we reviewed these frontiers for readers.