探讨苦参素联合干扰素α对慢性乙型肝炎患者肝纤维化指标与细胞免疫状态的影响

Investigate the Effects of Matrine Combined with Interferon-alpha on Hepatic Fibrosis and Cellular Immunity in Patients with Chronic Hepatitis B

目的探讨苦参素联合干扰素α对慢性乙型肝炎患者肝纤维化指标与细胞免疫状态的影响.方法将我感染科自2009年1月至2019年3月收治的150例确诊为慢性乙型肝炎患者作为观察对象,并按照其入院先后顺序的原则分为观察组及对照组两组,其中对照组给予干扰素α实施治疗,观察组则以苦参素联合干扰素α实施治疗,连续治疗2个月后分析两组患者的肝功能、肝纤维化指标及细胞免疫变化情况.结果分析结果显示,观察组患者肝功能及肝纤维化指标改善明显,且与对照组比较,差异具有统计学意义;在患者细胞免疫方面,观察组患者的CD4+及NK细胞亚群水平明显增高,而CD8+水平下降明显,差异具有统计学意义.结论以苦参素联合干扰素α对慢性乙型肝炎患者进行治疗,可有效改善患者肝功能情况,改善其肝脏纤维化情况及细胞免疫状态,有助于改善患者预后.

Objective To analyze the effects of matrine combined with interferon alpha on hepatic fibrosis and the cellular immunity in patients with chronic hepatitis b. Methods The 150 patients diagnosed as chronic hepatitis b admitted to the infection department of our hospital from January 2009 to March 2019 were taken as observation objects who were divided into observation group and control group according to the principle of their admission sequence. The control group was treated with interferon alpha, while the observation group was treated with matrine combined with interferon alpha. After 2 months of treatment, we would analyze the liver function, hepatic fibrosis index and cellular immunity of the two groups. Results The analysis results showed that liver function and liver fibrosis indexes in the observation group improved significantly, and the difference was statistically significant compared with the control group;In terms of patients’ cellular immunity, the proportion of CD4+ and NK cell subgroups in the observation group increased significantly while the proportion of CD8+ decreased significantly, and the difference was statistically significant. Conclusion The treatment with matrine combined with interferon alpha can effectively improve the liver function, fibrosis and cellular immunity of patients with chronic hepatitis b, and it can improve the prognosis of patients.