肝窦内皮细胞与肝再生的研究进展

Progress in research of liver sinusoidal endothelial cells and liver regeneration

肝脏在化学损伤或手术局部切除后能够再生,再生过程受实质性肝细胞和非实质细胞之间的动态相互作用。肝窦内皮细胞(LSECs)是肝脏非实质细胞中数量最多的细胞,参与肝脏发育、损伤和再生过程。越来越多的研究表明LSECs对肝细胞再生是必不可少的。本文就近年来LSECs与肝再生的研究进展综述,旨在通过靶向作用于LSECs为促进肝再生提供新思路。

Liver can be regenerated after chemical injury or localized resection of the surgery by dynamic interactions between hepatocytes and non-parenchymal cells. Liver sinusoidal endothelial cells (LSECs) are the most abundant cells in liver non-parenchymal cells and participate in liver development, injury and regeneration. Currently more and more studies have shown that LSECs are essential for hepatocyte regeneration. In this paper, we summarized the research progress of LSECs and liver regeneration in recent years, aiming to provide new ideas for promoting liver regeneration by targeting LSECs.