肝内胆管结石演变为肝内胆管癌胆管局部微环境的变化

Changes of local microenvironment in the evolution of intrahepatic cholelithiasis to intrahepatic cholangiocarcinoma

肝胆管结石病是一种亚洲地区很常见的肝胆疾病。肝胆管结石的反复发作易诱发肝内胆管癌的发生。伴发的肝内胆管癌一般起病隐匿,常被结石引起的相关临床症状所掩盖,容易导致漏诊而延误最佳治疗时机。本文通过对肝内胆管结石相关肝内胆管癌疾病进行分析,阐述了肝内胆管结石进展到肝内胆管癌的组织局部微环境变化,试图寻找出肝内胆管结石进展为肝内胆管癌的相关危险因素,为临床治疗肝内胆管癌提供新的研究方向。

Hepatolithiasis is a very common hepatobiliary disease in Asia. Recurrent hepatolithiasis frequently lead to incidence of intrahepatic cholangiocarcinoma. The associated intrahepatic cholangiocarcinoma is generally hidden and often covered up by the related clinical symptoms caused by stones, which can easily lead to missed the best time of diagnosisand treatment. This paper mainly showed the diseases of intrahepatic cholangiocarcinoma associated with intrahepatic cholelithiasis, and expounded the changes of local microenvironment of bile duct tissue from intrahepatic cholelithiasis to intrahepatic cholangiocarcinoma. The purpose of this study is to look for the risk factors related to the development of intrahepatic cholelithiasis to intrahepatic cholangiocarcinoma and to provide a new research direction for the clinical treatment of intrahepatic cholangiocarcinoma.