摘要
目的了解聚乙二醇化重组人粒细胞集落刺激因子(PEG-rhG-CSF)在本院妇科肿瘤患者中的使用情况,为合理使用PEG-rhG-CSF提供参考。方法参考国内外指南、药品说明书并结合专家咨询,建立妇科肿瘤放/化疗过程中PEG-rhG-CSF的药物利用评价(DUE)标准。用回顾性分析方法,通过医院病例检索系统随机抽取2018年6月至2018年12月入住我院妇科病房的200例患者,共计965例次使用PEG-rhG-CSF的病历。结果 PEG-rhG-CSF的DUE标准包括用药适应证、用药过程和用药结果 3部分,结果发现,本院PEGrhG-CSF应用的不合理现象主要为用法用量不合理(97. 29%)和用药适应证不合理(39. 90%)。结论 PEG-rhG-CSF在妇科肿瘤中DUE标准的建立,可为临床医师和临床药师合理应用该药提供参考。
Objective To understand the use of PEG - rhG - CSF ( pegylated recombinant human granulocyte - colony stimulating factor) in patients with gynecologic tumors in our hospital,and to provide reference for the rational use of PEG - rhG - CSF. Methods Based on the domestic and foreign guidelines,package inserts and expert consultation,a drug use evaluation ( DUE) criteria for the use of PEG - rhG - CSF in gynecology during the chemoradiotherapy was established. A retrospective analysis method was used to randomly select 200 patients who were treated with PEG - rhG - CSF in the gynecological ward of our hospital from June to December 2018 and 965 cases of medical records were collected. Results The DUE criterion for PEG - rhG - CSF consisted of medication indication,medication course and medication results. The results showed that the irrational use of PEG - rhG - CSF mainly manifested in unreasonable usage or dosage ( 97. 29%),and indicative use of drugs ( 39. 90%). Conclusion The establishment of DUE criteria for PEG - rhG - CSF can provide a reference for physicians and clinical pharmacists to rationally apply for this drug.
作者
乐凯迪
刘敏
张元
闫加庆
马颖林
李国辉
LE Kai-di;LIU Min;ZHANG Yuan;YAN Jia-qing;MA Ying-lin;LI Guo-hui(Department of Pharmacy, National Cancer Centre / Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2019年第14期1518-1521,共4页
The Chinese Journal of Clinical Pharmacology
基金
中国医学科学院医学与健康科技创新工程基金资助项目(2016-I2M-1-001)
关键词
聚乙二醇化重组人粒细胞集落刺激因子
妇科肿瘤
药物利用评价
合理用药
pegylated recombinant human granulocyte colony - stimulating factor injection
gynecological oncology
drug use evaluation
rational drug use