补肾活血颗粒对IgA肾病90例临床与病理分析

Clinical and Pathological Analysis of Kidney-nourishing and Blood-circulation Promoting Granules in 90 Patients with IgA Nephropathy

目的对原发性IgA肾病的临床与病理的特点及相互之间的联系进行研究,探讨其发生的过程以及补肾活血颗粒对IgA肾病的治疗作用。方法对我院2015年1月至2017年12月的90例IgA肾病患者依照根据间质纤维化或小管萎缩(T)的积分分为共9组。分别研究每组原发性IgA肾病病人的临床表现、病理特征等等。结果经过临床实验表明,间质纤维化/小管萎缩是原发性IgA肾病最常见的疾病类型。UPE、Scr、eGFR、尿NAG酶、ACR以及UPCR与IgAN肾组织病理分级显著相关。结论补肾活血颗粒对IgA肾病伴间质纤维化或小管萎缩的早期有明显的阻止进展作用。

Objective To study the clinical and pathological characteristics of patients with primary IgA nephropathy and the correlation between the characteristics and to discuss the occurrence process of the disease and the effect of Kidney-nourishing and blood-circulation promoting granules on the treatment of the disease. Methods According to the score in terms of interstitial fibrosis or tubular atrophy (T),90 patients with primary IgA nephropathy who were treated in Xianyang Vocational Technical College from January 2015 to December 2017 were divided into nine groups,and the clinical features and pathological characteristics of each group were studied separately.Results Clinical trials showed that interstitial fibrosis/tubular atrophy was the most common symptom of primary IgA nephropathy.UPE,Scr,eGFR,urinary NAG enzyme,ACR and UPCR were significantly associated with the pathological grading of nephridial tissue IgAN patients.Conclusion Kidney-nourishing and blood-circulation promoting granules can significantly suppress IgA nephropathy with interstitial fibrosis or tubule atrophy at the early stage.