秦皮乙素抗肿瘤作用及机制

Anti-cancer Effects and Mechanism of Esculetin

秦皮乙素是一种具有良好抗肿瘤活性的中药提取活性成分,特别是秦皮乙素的有效性和低毒性,使其在肿瘤治疗中的应用越来越广泛。研究表明秦皮乙素对肺癌、胃癌、肝癌、胰腺癌、肠癌、前列腺癌、乳腺癌、黑色素瘤、脑胶质瘤、骨髓瘤、白血病等肿瘤均有治疗作用,可以抑制细胞增殖、诱导细胞凋亡、阻滞细胞周期、抑制肿瘤转移、抑制血管生成、增强免疫力和增敏减毒等作用,这些研究为秦皮乙素的临床应用及药物开发提供实验基础。

Esculetin is one of the new anti-tumor traditional Chinese medicine monomers.Particularly effectivity and hypotoxicity of Esculetin has promoted its use in the tumor therapy.Esculetin was proved to have anti-cancer effects against lung cancer,gastric cancer,liver cancer,pancreatic cancer,colorectal cancer,prostate cancer,breastcancer,leukemia and other malignancies leukemia. Esculetin can inhibit cell proliferation,block cell cycle,induce apoptosis, inhibit metastasis and angiogenesis and enhance effects of chemotherapy. These studies provide the experimental basis for rational application and development of esculetin.