EGFR和DNA-PKcs与肺癌患者预后的关系

The Relationship Between EGFR and DNA-PKcs and Prognosis of Lung Cancer Patients

目的检测表皮生长因子受体(epidermal growth factor receptor,EGFR)和DNA依赖蛋白激酶催化亚基(DNA-dependent protein kinase catalytic subunit,DNA-PKcs)表达水平与非小细胞肺癌患者预后的关系。方法将2005年1月-2008年6月在我院手术的227例非小细胞肺癌患者根据免疫组化法染色结果分为四组:-、+、++、+++,分别比较EGFR和DNA-PKcs不同表达程度的患者之间生存时间的差异,随访至2018年8月。结果EGFR-、+、++、+++表达的患者例数分别为90例(40%)、50例(22%)、45例(20%)、42例(18%),中位生存时间分别为35、37、35、34个月(P>0.05)。DNA-PKcs-、+、++、+++表达的患者例数分别为59例(26%)、18例(8%)、40例(18%)、110例(48%),中位生存时间分别为37、34、32、33个月,阴性表达(-)和高表达(+++)之间差异具有统计学意义(P<0.05)。EGFR和DNA-PKcs共高表达的有27例。GFR和DNA-PKcs共高表达的患者中位生存时间为27个月,非高表达患者的中位生存时间为36个月,差异不具有统计学意义(P>0.05)。结论EGFR表达对非小细胞肺癌患者的预后无影响,DNA-PKcs阴性表达患者生存时间优于高表达(+++)患者,提示高表达患者的预后不良。

Objective To detect the relationship between the expression levels of EGFR and dna-pkcs and the prognosis of patients with nonsmall cell lung cancer.Methods From Jaruary 2005 to June 2008,227 patients with NSCLC surgery were divided into four groups according to immunohistochemical staining results:-,+,++,+++,respectively,to compare the difference in survival time between patients with different levels of EGFR and dna-pkcs expression.Follow-up until August 2018.Results The number of patients with EGFR-,+,++,+++expression was 90(40%),50(22%),45(20%)and 42(18%),respectively.The median survival time was 35,37,35 and 34 months(P>0.05).The number of patients with dna-pkcs-,+,++,+++expression was 59(26%),18(8%),40(18%)and110(48%),respectively.The median survival time was 37,34,32 and 33 months,respectively.The difference between negative expression(-)and high expression(+++)was significant(P<0.05).EGFR and dna-pkcs were highly expressed in 27 cases.The median survival time was 27 months in patients with co-high expression of GFR and dna-pkcs.The median survival time of patients without high expression was 36 months,with no significant difference(P>0.05).Conclusion EGFR expression has no effect on the prognosis of patients with non-small cell lung cancer,and the survival time of patients with negative dna-pkcs expression is significantly better than that of patients with high expression(+++),suggesting poor prognosis of patients with high expression.