NLRP3炎症小体与糖尿病性心肌病研究进展

Research progress of NLRP3 inflammasome in diabetic cardiomyopathy

糖尿病的重要心血管并发症之一是糖尿病心肌病(diabetic cardiomyopathy,DCM)。代谢紊乱、线粒体损伤、心肌细胞凋亡和自噬都被证实参与了DCM的发生、发展。近年来研究证实,核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎性小体可能与DCM的发生、发展密切相关,是DCM治疗的潜在靶点。该文总结了NLRP3炎性小体与DCM的研究进展,为未来治疗DCM提供新的方向。

Diabetic cardiomyopathy(DCM) is one of the important cardiovascular complications of diabetes mellitus.Metabolic disorders,mitochondrial damage,cardiomyocyte apoptosis and autophagy are involved in the development of DCM.Recent research demonstrates that NLRP3 inflammasome plays a vital role in the pathogenesis of DCM,and has emerged as a potential target for the treatment of DCM.In this article,research progress in NLRP3 inflammasome and DCM has been reviewed,aiming to provide novel therapeutic idea for the treatment of DCM.