预钙化处理提高钽的表面生物活性

Enhancement of the Bioactivity of Tantalum by Pre-Calcification

为提高钽的生物活性,对钽进行了NaOH溶液碱处理,利用模拟体液(SBF)浸泡实验探索碱处理的最佳浓度。碱处理后的钽又分别在CaCl2溶液和K2HPO4溶液中进行预钙化处理。钽经过0.7 mol/L的碱处理后,在SBF中浸泡2周,表面即可被羟基磷灰石覆盖。经预钙化处理后,钽在SBF中浸泡4 d,表面即可覆盖一层羟基磷灰石,说明预钙化大幅提高了钽的生物活性。其机理是预钙化处理可使样品表面迅速完成钙磷化合物的形核,浸入SBF以后羟基磷灰石可以迅速长大。

In order to improve the bioactivity of tantalum, NaOH solution was applied to tantalum, and the optimal concentration of alkali treatment was explored by simulating somatic fluid (SBF) soaking experiment. Alkali-treated tantalum was pre-calcified in CaCl2 solution and K2HPO4 solution. After tantalum was treated by 0.7 mol/L alkali and soaked in SBF for 2 weeks, the surface can be covered with hydroxyapatite. After pre-calcification, tantalum was soaked in SBF for 4 d, and then the surface can be covered with a layer of hydroxyapatite, indicating that pre-calcification substantially increases the bioactivity of tantalum. The mechanism is that pre-calcification can make the sample surface quickly complete the nucleation of calcium and phosphorus compounds, and hydroxyapatite can grow rapidly after immersion in SBF.