肝移植术后新发糖尿病危险因素研究进展

Risk factors of new onset diabetes mellitus after liver transplantation: recent research progress

肝移植术后新发糖尿病(NODAT)是肝移植术后常见的并发症,因其发病率高、危害大,严重的影响移植物功能和受者生存质量,受到了广大学者的关注。NODAT的危险因素有许多,大致可分为不可调控性危险因素及可调控性危险因素。不可调控性危险因素主要包括年龄、性别、供肝脂肪变性、肝硬化、糖尿病家族史等;可调控性危险因素包括肥胖、钙调磷酸酶抑制剂、糖皮质激素、肝炎病毒感染、巨细胞病毒感染及移植前血糖等。笔者结合近年相关研究报道对NODAT的发生机制及危险因素进行综述。

New onset diabetes mellitus after transplantation(NODAT) is a common complication after liver transplantation and has attracted the attention of many scholars, for its high incidence and great harm, and severe influence on the function of the graft and the quality of life of the recipient. There are many risk factors for NODAT, which can be divided into non-regulable and regulable risk factors. The non-regulable risk factors include age, gender, donor liver steatosis, cirrhosis, and family history of diabetes. The regulable risk factors comprise obesity, calcineurin inhibitors, glucocorticoids, hepatitis virus infection, cytomegalovirus infection, and pre-transplant blood glucose. Here, the authors address the pathogenetic mechanism and risk factors for NODAT based on recent research reports.