女性盆底修复组织工程补片的研究现状

Tissue Engineering in Rehabilitate Female Pelvic Floor Dysfunction

盆底功能障碍性疾病是中老年女性的常见病、多发病,补片植入是其理想的手术治疗方式,临床上常用的聚丙烯补片力学性能好,但存在补片暴露、侵蚀等远期并发症,生物源性补片组织相容性好但力学性能不足。组织工程是应用生命科学与工程学的原理与技术,在正确认识哺乳动物正常及病理两种状态下的组织结构与功能关系的基础上,研究、开发用于修复、维护、促进人体各种组织或器官损伤后的功能和形态的生物替代物的一门新兴学科。组织工程技术应用于盆腔器官脱垂的治疗,既能满足盆底支持的力学要求,而其生物相容性又优于传统聚丙烯补片,且能在一定程度上促进组织修复,是临床补片植入治疗的迫切需求。现针对组织工程的研究进展进行概述,了解组织工程在治疗盆腔器官脱垂的应用情况并指导治疗。

Pelvic floor dysfunction is a common and frequently-occurring disease in middle-aged and elderly women.Patch implantation is an ideal surgical treatment.Polypropylene-based filler material has been suggested as a common method to rehabilitate the pelvic support structure,but there are complications such as exposure and erosion.Biogenic patches have good tissue compatibility but insufficient mechanical properties.Tissue engineering is a new discipline which the applied the principles and techniques of life sciences and engineering,based on a correct understanding of the relationship between tissue structure and function in normal and pathological conditions of mammals,researching and developing biological substitutes of function and morphology to repair,maintain and promote various tissues or organs damage of the human body.Tissue engineering technology is applied to the treatment of pelvic organ prolapse,which can meet the mechanical requirements of pelvic floor support,and its biocompatibility is superior to traditional polypropylene patch,and can promote tissue repair to a certain extent.It′s the urgent need for patch implantation therapy.This article outlines the research progress of tissue engineering,to understand and guide the application of tissue engineering in the treatment of pelvic organ prolapse.