铁死亡调控机制及其在卵巢癌中的研究进展

Mechanisms of Ferroptosis and Its Involvement in Ovarian Cancer

卵巢癌作为一种恶性程度极高的女性生殖系统肿瘤,其死亡率在妇科恶性肿瘤中高居首位。卵巢癌发病隐匿,早期缺乏特异检测手段,在中晚期阶段往往发展为复发性及多重耐药性疾病,预后较差。近年来相关研究发现,铁死亡在卵巢癌的发生、发展中起着重要作用。许多学者认为铁死亡作为一种铁依赖性的细胞死亡方式,与多种生物化学过程密切相关,可以通过剥夺癌细胞内的铁或者改变肿瘤组织铁离子代谢方式,抑制肿瘤组织增殖,将其视为卵巢癌的潜在治疗靶点。现就铁死亡的生化过程及其在卵巢癌中的研究进展进行综述,为卵巢癌的治疗提供新思路。

Ovarian cancer,as a kind of female reproductive system tumor with extremely high malignant degree,is the leading cause of death in gynecologic malignancies.Ovarian cancer is insidious and lacks specific detection methods at the early stage.It often develops into recurrent and multi-drug resistant diseases in the middle and late stages,with poor prognosis.In recent years,relevant basic and clinical studies have found that ferroptosis plays an important role in the development of ovarian cancer.Many scholars believe that iron death,as an iron-dependent cell death mode,is closely related to a variety of biochemical processes and can inhibit the proliferation of tumor tissues by depriving iron in cancer cells or changing the metabolism of iron ions in tumor tissues.Moreover,iron death was also identified as a potential therapeutic target for ovarian cancer.This paper summarizes the biochemical process of iron death and its research progress in ovarian cancer,and provides new ideas for the treatment of ovarian cancer.