阿托伐他汀钙治疗老年急性脑梗死的疗效及其对患者神经功能及脑梗死体积的影响

Effect of atorvastatin calcium on neurological function and cerebral infarction volume in elderly patients with acute cerebral infarction

目的观察阿托伐他汀钙对老年急性脑梗死的疗效,并探究其对患者神经功能及脑梗死体积的影响。方法选取2015年1月至2018年1月长庆油田职工医院神经内科收治的96例老年急性脑梗死患者为研究对象,按照随机数表法将患者分为观察组和对照组,每组48例。对照组患者采取常规治疗,观察组在对照组治疗的基础上应用阿托伐他汀钙治疗,疗程均为24周。比较两组患者治疗后的临床效果、血清指标、神经功能评分(NHISS)、脑梗死体积及基质金属蛋白酶-9(MMP-9)、超敏C-反应蛋白(hs-CRP)水平、白介素细胞-6(IL-6)、肿瘤坏死因子(TNF-α)及C反应蛋白(CRP)。结果观察组患者的治疗总有效率为89.58%,明显高于对照组的56.25%,差异具有统计学意义(P<0.05);治疗后,观察组患者的CRP、IL-6和TNF-α分别为(8.84±5.63)mg/L、(6.77±1.89)ng/L和(17.80±6.67)ng/L,明显低于对照组的(12.30±8.97)mg/L、(8.33±2.73)ng/L和(31.63±7.45)ng/L,差异均具有统计学意义(P<0.05);治疗后,观察组患者的脑梗死体积和NHISS评分分别为(2.27±1.13)cm^3、(2.54±1.41)分,明显低于对照组的(4.52±1.22)m^3、(5.34±1.40)分,差异均具有统计学意义(P<0.05);治疗后,观察组患者的hs-CRP和MMP-9分别为(3.29±1.59)mg/L和(75.66±1.29)ng/mL,明显低于对照组的(5.94±2.31)mg/L和(88.64±1.73)ng/mL,差异均具有统计学意义(P<0.05)。结论阿托伐他汀钙治疗老年急性脑梗死可促进患者神经功能恢复、降低炎症反应、缩小患者脑梗死体积,临床治疗效果显著。

Objective To observe the efficacy of atorvastatin calcium in the treatment of elderly patients with acute cerebral infarction(ACI), and to explore its effect on neurological function and cerebral infarction volume.Methods A total of 96 elderly patients with acute cerebral infarction, who admitted to Department of Neurology of the Staff Hospital of Changqing Oilfield from January 2015 to January 2018 were selected and divided into the observation group and the control group according to random number table method. The patients in the control group were treated with conventional treatment, and the patients in observation group were treated with atorvastatin calcium on the basis of the treatment of the control group. The course of treatment was 24 weeks. The clinical effect, serum index,neurological function score(NHISS), volume of cerebral infarction, matrix metalloproteinase-9(MMP-9), interleukin 6(IL-6), tumor necrosis factor(TNF-α) and hypersensitive C-reactive protein(hs-CRP) were compared between the two groups. Results The total effective rate of the patients in the observation group was 89.58%, which was significantly higher than 56.25% in the control group(P<0.05). After treatment, the levels of hs-CRP, IL-6 and TNF-α in the observation group were(8.84±5.63) mg/L,(6.77±1.89) ng/L and(17.80±6.67) ng/L, respectively, which were significantly lower than corresponding(12.30±8.97) mg/L,(8.33±2.73) ng/L and(31.63±7.45) ng/L in the control group(all P<0.05);the cerebral infarction volume and NHISS score in the observation group were(2.27±1.13) cm^3 and 2.54±1.41, which were significantly lower than corresponding(4.52±1.22) m^3 and 5.34±1.40 in the control group(all P<0.05);the hs-CRP and MMP-9 of the patients in the observation group were(3.29 ± 1.59) mg/L and(75.66 ± 1.29) ng/mL, respectively,which were significantly lower than corresponding(5.94±2.31) mg/L and(88.64±1.7) mg/mL in the control group(all P<0.05). Conclusion Atorvastatin calcium can promote the recovery of neurological function, reduce inflammatory reaction and the volume of cerebral infarction in elderly patients with acute cerebral infarction, and the clinical treatment effect is remarkable.