妊娠相关血浆蛋白-A、超敏C反应蛋白与妊娠期高血压疾病的关系

Relationship between pregnancy-associated plasma protein-A,hypersensitive C-reactive protein and hypertensive disorder complicating pregnancy

目的探讨妊娠期高血压疾病患者血清妊娠相关血浆蛋白-A(PAPP-A)、超敏C反应蛋白(hs-CRP)水平的变化及临床意义。方法选择2017年1月至2018年12月期间榆林市中医医院妇产科收治的84例妊娠期高血压疾病患者纳入观察组,其中40例妊娠期高血压纳入高血压组,30例子痫前期轻度患者纳入轻度组,14例子痫前期重度患者纳入重度组,以同期在我院门诊随诊的40例健康孕妇纳入对照组。检测并比较四组受检者的血清PAPP-A、hs-CRP水平,并分析两者的相关性。结果观察组患者的血清hs-CRP、PAPP-A水平分别为(7.74±2.73)mg/L、(12.13±4.78)mU/L,明显高于对照组的(2.83±1.05)mg/L、(7.25±2.39)mU/L,差异均有统计学意义(P<0.05);妊娠期高血压疾病患者血清hs-CRP、PAPP-A水平均随着病情的加重而逐级增加,差异均有统计学意义(P<0.05);相关性分析显示,妊娠期高血压疾病患者血清hs-CRP与PAPP-A间存在显著正相关性(r=0.452,P<0.05)。结论血清hs-CRP、PAPP-A水平与妊娠期高血压疾病的发生、发展关系密切,临床上检测孕妇血清hs-CRP、PAPP-A水平的变化对预测、诊断妊娠期高血压疾病具有重要的参考价值。

Objective To investigate the changes and clinical significance of serum hypersensitive C-reactive protein (hs-CRP) and pregnancy-associated plasma protein-A (PAPP-A) levels in patients with hypertensive disorder complicating pregnancy. Methods From January 2017 to December 2018, 84 cases of hypertensive disorder complicating pregnancy treated in Department of Obstetrics and Gynecology, Yulin Chinese Medicine Hospital were selected as the observation group, including 40 cases of hypertensive disorders of pregnancy (hypertension group), 30 cases of mild preeclampsia (mild group), 14 cases of severe preeclampsia (severe group). Forty healthy pregnant women treated in our hospital during the same period were selected as the control group. The serum levels of PAPP-A and hs-CRP were detected and compared among the four groups, and the correlation between them was analyzed. Results The serum levels of hs-CRP and PAPP-A in the observation group were (7.74±2.73) mg/L and (12.13±4.78) mU/L, which were significantly higher than (2.83±1.05) mg/L and (7.25±2.39) mU/L in the control group (P<0.05). The levels of hs-CRP and PAPP-A in hypertensive disorder complicating pregnancy increased with the aggravation of the disease, and the difference was statistically significant (P<0.05). Correlation analysis showed that there was a significant positive correlation between serum hs-CRP and PAPP-A in hypertensive disorder complicating pregnancy (r=0.452, P<0.05). Conclusion Serum hs-CRP and PAPP-A levels are closely related to the occurrence and development of hypertensive disorder complicating pregnancy. Clinical detection of changes of serum hs-CRP and PAPP-A levels in pregnant women has important reference value in predicting and diagnosing hypertensive disorder complicating pregnancy.