急性脑出血患者早期外周血干扰素-γ、hs-CRP水平与预后的关系

Relationship between the peripheral blood IFN-γ and hs-CRP and prognosis in patients with acute cerebral hemorrhage

目的探讨急性脑出血患者早期外周血干扰素-γ(IFN-γ)、超敏C反应蛋白(hs-CRP)水平与预后的关系。方法选择2017年1月至2018年12月期间咸阳市第一人民医院神经内科收治的106例急性脑出血患者纳入观察组,选取同期在本院体检的100例健康者纳入对照组,测定并比较两组受检者的血清hs-CRP、IFN-γ水平,同时根据脑出血量将患者分为少量出血组(n=35)、中量出血量组(n=46)和大量出血组(n=25);根据神经功能缺损情况将患者分为轻型组(n=33)、中型组(n=46)和重型组(n=27);根据患者的预后情况将患者分为预后良好组(n=60)和预后不良组(n=46)。结果观察组患者的血清IFN-γ、hs-CRP水平分别为(122.39±42.58)pg/mL、(11.63±3.52)mg/L,明显高于对照组的(65.46±21.79)pg/mL、(3.27±1.19)mg/L,差异均有统计学意义(P<0.05);血清IFN-γ、hs-CRP水平在少量、中量、大量出血组患者中依次升高,差异均有统计学意义(P<0.05);血清IFN-γ、hs-CRP水平在轻型、中型、重型神经缺损出血组患者中也依次升高,差异均有统计学意义(P<0.05);预后不良组患者的血清IFN-γ、hs-CRP水平分别为(148.75±44.56)pg/mL、(14.16±4.29)mg/L,明显高于预后良好组的(94.46±28.34)pg/mL、(9.98±3.46)mg/L,差异均有统计学意义(P<0.05);相关性分析结果显示,急性脑出血患者血清IFN-γ与hs-CRP水平呈正相关性(r=4.026,P<0.05)。结论急性脑出血患者早期检测血清IFN-γ、hs-CRP水平有助于在一定程度上判断患者的病情程度,预测患者的预后。

Objective To investigate the relationship between the levels of Interferon-γ(IFN-γ) and hs-CRP in peripheral blood and prognosis in patients with acute cerebral hemorrhage. Methods A total of 106 cases of patients with acute cerebral hemorrhage, who admitted to Department of Neurology of the First People’s Hospital of Xianyang City from January 2017 to December 2018 were enrolled in the observation group, and 100 healthy persons were enrolled in the control group. Serum hs-CRP and IFN-gamma levels were measured. At the same time, according to the amount of cerebral hemorrhage, the patients were divided into the small amount hemorrhage group(n=35), medium amount hemorrhage group(n=46), large amount hemorrhage group(n=25);according to the situation of neurological deficits, the patients were divided into the light group(n=33), medium group(n=46), and severe group(n=27). According to the prognosis of the patients, patients were divided into the good prognosis group(n=60) and poor prognosis group(n=46). Results The levels of serum IFN-γ and hs-CRP in the observation group were(122.39±42.58) pg/mL and(11.63±3.52) mg/L, respectively, which were significantly higher than(65.46±21.79) pg/mL and(3.27±1.19) mg/L in the control group(P<0.05);the levels of serum IFN-γ and hs-CRP in the small, medium and massive bleeding groups increased in turn, with significant difference(all P<0.05). The levels of serum IFN-γ and hs-CRP in patients with mild, moderate and severe cerebral hemorrhage increased in turn, with statistical significance(all P<0.05);the levels of serum IFN-γ and hs-CRP in patients with poor prognosis were(148.75 ± 44.56) pg/mL and(14.16 ± 4.29) mg/L, which was significantly higher than corresponding(94.46±28.34) pg/mL and(9.98±3.46) mg/L in patients with good prognosis(P<0.05). The correlation analysis showed that acute cerebral hemorrhage were positively correlated with serum IFN-γ and hs-CRP in patients(r=4.026, P<0.05). Conclusion To some extent, early detection of serum IFN-γ and hs-CRP in patients with acute cerebral hemorrhage is helpful to judge the patient’s condition and predict the prognosis of the patients.