透皮给药实心微针阵列的紫外压印工艺方法

Ultraviolet Imprinting Technology of Fabricating Transdermal Drug Delivery Microneedle Arrays

文中提出了一种紫外压印技术成型透皮给药实心微针的工艺方法,以C-coating光刻胶作为微针成型的原材料,采用微机电技术加工的聚二甲基硅氧烷(PDMS)微针模具,探究了紫外压印实验中影响微针成型质量的工艺条件。实验结果表明,利用C-coating光刻胶抽真空12 min以上,紫外曝光170~200 s时,制备的紫外压印微针的高度能达到230μm。通过纳米压痕力学测试和猪皮离体皮肤穿刺实验,证明这种紫外压印微针的针尖在承受50 mN的力时没有发生断裂破坏现象,并且能够顺利刺入猪皮达到良好的透皮给药效果,为紫外压印技术成型透皮给药微针提供了一定的技术参考。

This paper mainly proposed a method of fabricating transdermal drug delivery microneedle arrays by ultraviolet printing technology.The C-coating photoresist was used as raw material for fabricating the microneedles,and the microneedle mold of polydimethylsiloxane(PDMS)was processed by microelectromechanical technology.In the UV imprinting experiment,the technological conditions that affects the quality of the microneedles were explored.When the C-coating photoresist was pumped for more than 12 min and the time of UV exposure was between 170 s to 200 s,the experimental results show that the height of the UV imprint microneedles can reach 230μm.The nano-indentation mechanics test shows that the tips of the UV imprinted microneedles have no rupture and destruction when it bears the force of 50 mN,and the pigskin puncture experiment shows that the UV imprinted microneedles can penetrate the pigskin smoothly and perform a good transdermal delivery effect.This study provided a supporting technology for the fabrication of transdermal drug delivery microneedles by UV imprint technology.