加味萆薢分清汤治疗慢性非细菌性前列腺炎的效果

Effect of Modified Bixie Fenqing Decoction in the treatment of chronic nonbacterial prostatitis

目的 分析加味萆薢分清汤治疗慢性非细菌性前列腺炎的效果.方法 回顾性分析长沙市第四医院泌尿外科2017年1月~2018年3月收治的80例慢性非细菌性前列腺炎患者的临床资料,根据治疗方法不同分为对照组和观察组,每组各40例.对照组患者采用舍尼通片治疗,观察组患者采用加味草薢分清汤治疗.比较两组患者治疗前后美国国立卫生研究院慢性前列腺炎症状指数(NIH-CPSI)评分、前列腺液中性激素[睾酮(T)、雌二醇(E2)、泌乳素(PRL)]、肿瘤坏死因子-α(TNF-α)、巨噬细胞炎性蛋白-1α(MIP-1α)、环氧化酶-2(COX-2)、前列腺素(PGE2)、尿动力学水平情况.结果 治疗前,两组患者NIH-CPSI评分、尿动力学(最大尿流率、平均尿流率)比较,差异无统计学意义(P>0.05).两组患者治疗后NIH-CPSI评分较治疗前下降,尿动力学较治疗前上升,且观察组患者治疗后NIH-CPSI评分低于对照组,尿动力学高于对照组,差异有统计学意义(P<0.05).治疗前,两组患者性激素、TNF-α、MIP-1α、COX-2、PGE2水平比较,差异无统计学意义(P>0.05).治疗后两组患者前列腺液中T水平较治疗前上升,E2、TNF-α、MIP-1α、COX-2、PGE2水平较治疗前下降,且观察组患者治疗后T水平高于对照组,E2、TNF-α、MIP-1α、COX-2、PGE2水平低于对照组,差异有统计学意义(P<0.05),但两组PRL水平比较,差异无统计学意义(P>0.05).结论 加味萆薢分清汤治疗慢性非细菌性前列腺炎效果较好,可有效改善尿流率,值得临床推广应用.

Objective To analyze the effect of Modified Bixie Fenqing Decoction in the treatment of chronic nonbacterial prostatitis.Methods Clinical data of 80 patients with chronic nonbacterial prostatitis admitted to Department of Urology of the Fourth Hospital of Changsha City from January 2017 to March 2018 was retrospectively analyzed.According to different treatment methods,they were divided into the control group and the observation group,with 40 cases in each group.The control group was treated by Cernilton Tablets,and the observation group was treated by Modified Bixie Fenqing Decoction.The scores of National Institutes of Health chronic prostatitis symptom index(NIH-CPSI),sex hormones[testosterone(T),estradiol(E2),prolactin(PRL)]in the prostatic fluid,tumor necrosis factor alpha(TNF-α),macrophage inflammatory protein-1 alpha(MIP-1α),cyclooxygenase-2(COX-2),prostaglandin(PGE2)and the level of urodynamics of the two groups were compared before and after treatment.Results Before treatment,there were no statistically significant differences in NIH-CPSI score and urodynamics(maximum urine flow rate and average urine flow rate)between the two groups(P>0.05).After treatment,the NIH-CPSI score of the two groups was decreased compared with that before treatment,and the urodynamics was increased compared with that before treatment.Moreover,the NIH-CPSI score of the observation group was lower than that of the control group,and the urodynamics was higher than that of the control group,the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in levels of sex hormone,TNF-α,MIP-1α,COX-2,PGE2 between the two groups(P>0.05).After treatment,the levels of T in prostatic fluid of the two groups were increased,while the levels of E2,TNF-α,MIP-1α,COX-2,PGE2 were decreased compared with those before treatment.The level of T of the observation group was higher than that of the control group,and the levels of E2,TNF-α,MIP-1α,COX-2 and PGE2 were lower than those of the control group,the differences were statistically signficant(P<0.05).However,there was no statistically significant difference of PRL levels between the two groups(P>0.05).Conclusion Modified Bixie Fenqing Decoction has good effect for the treatment of chronic nonbacterial prostatitis,which can effectively improve urine flow rate,and it is worthy of clinical popularization and application.