精神分裂症患者外周血细胞计数水平及其与临床症状的相关性研究

Study on the level of peripheral blood cell count and its correlation with clinical symptoms in patients with schizophrenia

目的探讨精神分裂症患者外周血细胞计数水平及其与临床症状之间的相关性。方法纳入精神分裂症患者138例(病例组),健康对照者141名(对照组)。所有受试者均接受血常规检测,并采用阳性和阴性症状量表(PANSS)评估病例组的临床症状。结果病例组WBC、NEU、LYM及MON均高于对照组,NLR、PLR均低于对照组,差异有统计学意义(P<0.05);病例组抑郁因子与PLR、SIII呈正相关(P<0.05)。结论精神分裂症患者存在免疫异常,与其抑郁症状有关。

Objective To investigate the level of peripheral blood cell count and its correlation with clinical symptoms in patients with schizophrenia. Methods A total of 138 patients with schizophrenia(case group) and 141 healthy controls(control group) were enrolled. All subjects underwent routine blood tests and the positive and negative symptom scale(PANSS) were used to evaluate the clinical symptoms of the case group. Results WBC, NEU, LYM and MON in the case group were higher than those in the control group, while NLR and PLR were lower than those in the control group, with statistically significant differences( P <0.05). Depression factors in case group were positively correlated with PLR and SIII(P<0.05). Conclusion Patients with schizophrenia have dysimmunity, which is related to their depressive symptoms.