丁苯酞联合依达拉奉治疗急性脑梗死的效果及对患者神经功能的影响

Effect of butylphthalide combined with edaravone on acute cerebral infarction and its influence on neurological function of patients

目的探讨丁苯酞联合依达拉奉治疗急性脑梗死(ACI)的效果及对患者神经功能的影响。方法选取2015年5月至2018年7月于本院接受治疗的ACI患者148例,按照序贯随机法将其分为对照组与观察组,各74例。对照组采用依达拉奉注射液治疗,观察组在对照组的基础上采用丁苯酞口服治疗。比较两组日常生活能力、神经功能缺损情况、脑梗死面积、6-酮-前列腺素F1α、血清血栓素B2水平、治疗效果与不良反应发生情况。结果治疗后,两组BI评分明显高于治疗前,NIHSS评分明显低于治疗前,脑梗死面积明显小于治疗前,且观察组优于对照组,差异具有统计学意义(P<0.05)。治疗后,两组6-酮-前列腺素F1α水平明显高于治疗前,血清血栓素B2水平明显低于治疗前,且观察组优于对照组,差异具有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。观察组不良反应总发生率与对照组比较,差异无统计学意义(P>0.05)。结论丁苯酞与依达拉奉联合治疗可有效改善ACI患者预后,减轻神经功能损伤程度,值得推广使用。

Objective To investigate the effect of butylphthalide combined with edaravone on acute cerebral infarction(ACI)and its influence on neurological function of patients.Methods A total of 148 patients with ACI treated in our hospital from May 2015 to July 2018 were selected and divided into control group and observation group according to sequential random method,with 74 cases in each group.The control group was treated with edaravone injection,while the observation group was treated with butylphthalide orally on the basis of the control group.The daily living ability,neurological deficit,cerebral infarction area,levels of 6-keto-prostaglandin F1αand serum thromboxane B2,therapeutic effects and adverse reactions were compared between the two groups.Results After treatment,the BI score of the two groups were significantly higher than those before treatment,the NIHSS scores were significantly lower than those before treatment,the area of cerebral infarction were significantly smaller than those before treatment,and those of the observation group were better than the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of 6-keto-prostaglandin F1αof both groups were significantly higher than those before treatment,and the levels of serum thromboxane B2 were significantly lower than those before treatment,and those of the observation group were better than the control group(P<0.05).The total effective rate of treatment in the observation group was higher than that of the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion Butylphthalide combined with edaravone can effectively improve the prognosis of ACI patients and reduce the degree of neurological deficit,which is worth promoting and using.