不同剂量阿托伐他汀治疗短暂性脑缺血发作的临床效果

Clinical effect of different doses of atorvastatin in the treatment of transient ischemic attack

目的探讨不同剂量阿托伐他汀治疗短暂性脑缺血发作的临床效果。方法选取我院2017年6月至2018年4月收治的短暂性脑缺血发作患者98例,采用抽签法将其分为对照组(49例,给予20mg阿托伐他汀治疗)和试验组(49例,给予40mg阿托伐他汀治疗)。比较两组的住院期间再发作率、出院1年后转归情况及不良反应发生情况。结果试验组住院期间再发作率明显低于对照组(P<0.05)。试验组出院1年后的转归情况(复发率、梗死率、冠脉事件率、出血率)优于对照组(P<0.05)。试验组不良反应总发生率明显低于对照组(P<0.05)。结论与小剂量阿托伐他汀相比,采用大剂量阿托伐他汀治疗短暂性脑缺血发作患者的效果更好,患者住院期间再发作率更低,出院1年后转归情况更好,不良反应发生率较低,值得进一步推广使用。

Objective To investigate the clinical effect of different doses of atorvastatin in the treatment of transient ischemic attack.Methods A total of 98 patients with transient ischemic attack admitted in our hospital from June 2017 to April 2018 were selected and divided into control group(49 cases,given 20 mg atorvastatin treatment)and experimental group(49 cases,given 40 mg atorvastatin treatment)by random lottery method.The incidence of recurrence during hospitalization,the outcome of one year after discharge and the adverse reactions were compared between the two groups.Results The recurrence rate during hospitalization in the experimental group was significantly lower than that in the control group(P<0.05).The outcome(recurrence rate,infarction rate,coronary event rate and bleeding rate)in the experimental group at one year after discharge were better than those in the control group(P<0.05).The total incidence of adverse reactions in the experimental group was significantly lower than that in the control group(P<0.05).Conclusion Compared with low-dose atorvastatin,high-dose atorvastatin is more effective in the treatment of patients with transient ischemic attack,with lower recurrence rate during hospitalization,better outcomes at one year after discharge and lower incidence of adverse reactions.It is worthy of further promotion and application.