常规抗心衰药物联合β受体阻滞剂治疗心力衰竭的效果

Effect of routine anti-heart failure drugs combined with β-blocker in the treatment of heart failure

目的评价常规抗心衰药物联合β受体阻滞剂治疗心力衰竭的效果。方法将我院收治的124例心力衰竭患者采用单双号法分为对照组和试验组,各62例。对照组给予常规抗心衰药物治疗,试验组给予常规抗心衰药物联合β受体阻滞剂治疗,治疗周期均为2个月。比较两组的治疗效果。结果治疗前,两组患者LVEF、LVD、LVS、LVEDV、LVESV比较,差异无统计学意义(P>0.05);治疗后,两组患者LVEF均升高,LVD、LVS、LVEDV、LVESV均降低,且试验组均优于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者NYHA心功能分级比较,差异无统计学意义(P>0.05);治疗后,试验组NYHA心功能分级≤Ⅱ级患者的比例高于治疗前,差异有统计学意义(P<0.05)。治疗前,两组患者6min步行试验距离比较,差异无统计学意义(P>0.05);治疗后,两组6min步行试验距离均增长,且试验组长于对照组,差异有统计学意义(P<0.05)。两组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。结论常规抗心衰药物联合β受体阻滞剂治疗心力衰竭效果显著,且安全性高,值得临床应用推广。

Objective To evaluate the effect of routine anti-heart failure drugs combined withβ-blocker in the treatment of heart failure.Methods A total of 124 patients with heart failure admitted in our hospital were divided into control group and experimental group according to even and odd number method,with 62 cases in each group.The control group was treated with routine anti-heart failure drugs,and the experimental group was treated with routine anti-heart failure drugs combined withβ-blocker.The treatment period of both groups was 2 months.The therapeutic effects of the two groups were compared.Results Before treatment,there were no significant differences in LVEF,LVD,LVS,LVEDV and LVESV between the two groups(P>0.05);after treatment,LVEF in both groups increased,LVD,LVS,LVEDV and LVESV decreased,and those in the experimental group were better than the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in NYHA cardiac function classification between the two groups(P>0.05);after treatment,the proportion of patients with NYHA cardiac function≤grade II in the experimental group was higher than that before treatment,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the distance of 6-minute walking test between the two groups(P>0.05);after treatment,the distance of 6-minute walking test increased in both groups,and that in the experimental group was longer than the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidences of adverse reactions between the two groups(P>0.05).Conclusion Routine anti-heart failure drugs combined withβ-blocker has a significant effect in the treatment of heart failure,and with high safety,which is worthy of clinical application and promotion.