激素在丙种球蛋白无反应性川崎病中治疗效果的研究

Therapeutic effect of hormones in Kawasaki disease and sensitivity analysis of no response to gamma globulin

目的:研究糖皮质激素在丙种球蛋白无反应性川崎病中的治疗效果研究。方法:纳入2010年7月至2017年7月,入院治疗的220例川崎病患儿,对照组给予静脉丙种球蛋白及口服阿司匹林治疗,研究组在此基础上加用激素治疗,对于出现无反应者增加激素治疗后评估患儿的临床症状及实验室相关指标结果。结果:研究组在热退时间上较对照组消退快(P<0. 05),研究组在WBC及血浆白蛋白的含量上与对照组的差异有统计学意义(P<0. 05),比较两组丙种球蛋白反应与无反应患儿的临床特征均差异无统计学意义。对照组无反应与反应患儿主要在CRP、WBC、血浆白蛋白差异有统计学意义(P<0. 05),研究组在ESR、NT-proBNP、CRP、血浆白蛋白、PLT差异有统计学意义(P<0. 05)。结论:激素联合丙种球蛋白能增加患儿治疗效果,且增加丙种球蛋白不反应患儿的敏感性。

Objective: To study the therapeutic effect of glucocorticoids in Kawasaki disease and the sensitivity analysis of children with no response to gamma globulin. Methods: A total of 220 children with Kawasaki disease admitted to hospital from July 2010 to July 2017 were enrolled in the control group. Intravenous gamma globulin and oral aspirin were given. The study group added hormone therapy to the patients,and increased hormones for non-responders. The clinical symptoms and laboratory-related index result of the children were evaluated after treatment. Results: The heat loss time of the study group was faster than that of the control group ( P<0. 05). The WBC and plasma albumin levels in the study group were different from those in the control group ( P<0. 05). There were no statistical differences in the clinical features of the children. There were significant differences in CRP,WBC,and plasma albumin between the non-response and response groups in the control group ( P<0. 05). The study group had statistically significant differences in ESR,NT-proBNP,CRP, plasma albumin,and platelet count ( P<0. 05). Conclusions: Hormone combined with gamma globulin can increase the therapeutic effect of children and increase the sensitivity of children with gamma globulin.