联合治疗对急性脑梗死患者神经功能及日常生活能力的影响

Effect of alteplase thrombolysis on neurological function and daily living ability of patients with acute cerebral infarction

目的探讨阿替普酶联合阿司匹林对急性脑梗死患者神经功能及日常生活能力的影响。方法选择我院收治的急性脑梗死患者110例,按随机数表法分为两组,每组55例。对照组给予阿司匹林治疗,观察组给予阿替普酶联合阿司匹林治疗。比较两组临床疗效、神经功能、日常生活能力、血液流变学指标及不良反应情况。结果治疗2周后,两组总有效率比较,P<0.05;治疗2周、3个月后,两组美国国立卫生研究院卒中量表评分均降低,Barthel指数均升高,且观察组优于对照组,差异有统计学意义(P<0.05);治疗3个月后,两组全血黏度、纤维蛋白原、血浆黏度、红细胞压积均降低,观察组低于对照组,差异有统计学意义(P<0.05);治疗期间两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论阿替普酶联合阿司匹林治疗急性脑梗死临床疗效显著,能明显改善患者神经功能及日常生活能力,改善血液流变学,且安全性较高,值得临床推广。

Objective To explore the effects of alteplase thrombolysis on neurological function and daily living ability of patients with acute cerebral infarction.Methods A total of 110 patients with acute cerebral infarction were enrolled and randomly divided into two groups,55 cases in each group.The control group was given conventional drug treatment and the observation group was given alteplase thrombolysis on the basis of the control group.The clinical efficacy,neurological function,daily living ability,hemorheology index and adverse reactions were compared between the two groups. Results After 2 weeks of treatment,the total effective rate of the observation group was 90.91% and that of the control group was 76.37%,the difference was statistically significant (P<0.05);after 2 weeks and 3 months of treatment,the US National Health Research The Department of Stroke Scale (NIHSS) scores of the two groups all decreased and the Barthel index (BI) of the two groups all increased,the difference was statistically significant (P<0.05);after 3 months of treatment, the whole blood viscosity (WBV),fibrinogen (FIB),plasma viscosity (PV),hematocrit (HCT) of the two groups all decreased,the difference was statistically significant (P<0.05);the incidence of adverse reactions had not statistically significant difference between the two groups(P>0.05).Conclusion Alteplase thrombolytic therapy is effective in the treatment of acute cerebral infarction.It can significantly improve the neurological function and daily living ability of patients,improve blood rheology,which was safety and worthy of clinical promotion.