早年应激对唐山矿业人群血脂影响的调查

Study on the early stress effects on the blood lipid in Tangshan mining population

目的调查胎儿及婴儿期经历应激的个体成年后血脂异常患病情况,并分析其影响因素。方法本研究为横断面研究,共收集1260例开滦矿业集团职工的人口学特征,根据出生日期分为婴儿期地震暴露组372例,胎儿期地震暴露组382例,未暴露组506例,评估空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)指标的差异。结果婴儿期地震暴露组高胆固醇血症、混合型高脂血症患病率高于胎儿期地震暴露组(18.8%比11.3%、13.4%比6.8%,P<0.05);婴儿期地震暴露组血脂异常高于未暴露组(40.0%比27.7%,P<0.05)。单因素分析显示饮酒、体质指数(BMI)、地震应激分组是血脂异常的相关因素(χ2=4.432、6.612、7.690,P<0.05)。非条件Logistic回归分析结果显示,饮酒的血脂异常患病风险是不饮酒者的1.590倍(95%CI=1.102~2.294),婴儿期地震暴露组血脂异常患病风险是未暴露组的1.723倍(95%CI=1.147~2.589),BMI消瘦型较超重/肥胖型对血脂是一个保护性因素(OR=0.280,95%CI=0.080~0.972)。结论婴儿期应激暴露组高胆固醇血症、混合型高脂血症、血脂异常患病率较高,BMI消瘦型是血脂的保护因素,饮酒、婴儿期应激暴露是血脂异常的危险因素。

Objectives To investigate the prevalence of dyslipidemia in adults after stress in fetuses and infants, and to analyze the influencing factors. Methods This study is a cross-sectional study, recruited a total of 1 260 cases of the demographic characteristics from Kailuan Mining Group. According to the date of birth, there were 372 cases of infancy exposure group, 382 cases of fetal exposure group and 506 cases of unexposed group. The biochemical indexes of blood (FBG), triglyceride (TG), cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were evaluated. Results The rate of the prevalence of high TC hyperlipidemia and mixed hyperlipidemia in infant exposure group was higher than that of fetal exposure group (18.8% vs 11.3%,13.4% vs 6.8%,P< 0.05);the prevalence of dyslipidemia in infants exposure group was higher than that of unexposed group (40.0% vs 27.7%,P< 0.05). Single factor analysis of drinking, body mass index, and earthquake stress group were related factors of dyslipidemia (χ2 =4.432,6.612,7.690;P < 0.05). The unconditional Logistic regression analysis showed that the risk of dyslipidemia was 1.590 times as high as that of non drinkers (OR=1.590, 95%CI=1.102-2.294). The risk of dyslipidemia in infant exposure group was 1.723 times higher than that in the unexposed group (OR=1.723, 95%CI=1.147-2.589). The BMI wasting type was more protective than the overweight / obese type (OR=0.280, 95%CI=0.080-0.972). Conclusions The prevalence of high TC, mixed hyperlipidemia and dyslipidemia is higher in infants exposure group. Low body weight is a protective factor for dyslipidemia. Alcohol consumption and infant exposure are risk factors of dyslipidemia.