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Synthesis, Crystal Structure, Hirshfeld Surface Analysis and Biological Activity of 1-(Bis(4-methoxyphenyl)-methyl)-4-(2-(2-methylphenoxy)ethyl)piperazine 被引量:1

Synthesis, Crystal Structure, Hirshfeld Surface Analysis and Biological Activity of 1-(Bis(4-methoxyphenyl)-methyl)-4-(2-(2-methylphenoxy)ethyl)piperazine
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摘要 In this study, a novel phenoxyethylamine derivative 1-(bis(4-methoxy phenyl)-methyl)-4-(2-(2-methylphenoxy)ethyl)piperazine(C28 H35 N2 O3, Mr = 454.58) has been synthesized and its structure was characterized by 1 H NMR, 13 C NMR, HRMS and single-crystal X-ray diffraction. The compound crystallizes in triclinic system, space group P1 with a = 6.1980(12),b = 12.212(2), c = 19.527(4) ?, α = 93.08(3)°, β = 98.62(3)°, γ = 90.72(3)°, V = 1458.9(5) ?3, Z =2, Dc = 1.035 g/cm3, F(000) = 489, μ = 0.067 mm-1, Mo Kα radiation(λ = 0.71073 ?), the final R= 0.0693 and wR = 0.1759 for 3030 observed reflections with I > 2σ(I). The bioassay results indicated that the title compound 5 displayed effective activities against glutamine-induced neurotoxicity in PC12 cells.
作者 ZHONG Yan ZHU Yi-Jie GAO Ya-Rong XU Yi LI Ping WU Bin 仲琰;朱义杰;高雅蓉;许逸;李萍;吴斌(School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China;School of Pharmacy, Nanjing Medical University, Nanjing 211166, China;School of Basic Medical Sciences, Nanjing Medical University, Nanjing 210029, China)
出处 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2019年第7期1093-1098,共6页 结构化学(英文)
基金 Supported by the National Natural Science Foundation of China(No.81371451) the Natural Science Foundation of Jiangsu Province(No.BK20131390,BK20151444)
关键词 phenoxyethylamine crystal structure Hirshfeld surfaces analysis anti-ischemic activity phenoxyethylamine crystal structure Hirshfeld surfaces analysis anti-ischemic activity
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