7381例孕妇产前不规则抗体检测特异性分析及临床意义

The clinical significance of screening irregular blood group antibodies and detecting its specificity in pregnant women

目的:对在我院产检的孕妇进行血型不规则抗体筛查和抗体特异性检测,了解孕妇不规则抗体的检出情况及相关临床特征。方法:采用微柱凝胶卡,对2017年1月至2018年8月来我院产检的孕妇进行血型不规则抗体筛查,并对筛查阳性的标本进行抗体特异性鉴定分析。结果:7 381名孕妇中,32例检出不规则抗体,阳性率为0.434%,其中抗M 10例、抗E 3例、抗Ec 8例、抗D 4例、抗Lea 4例、抗Dia 1例、抗Wra 1例、冷抗体1例。以上检出不规则抗体的孕妇均具有1次以上的妊娠史。结论:本院孕妇的血型不规则抗体检出率为0.434%,其中抗M最多见。

Objective: To screen irregular blood group antibodies and detecte its specificity in pregnant women for exploring the presence of irregular antibodies and related clinical characteristics. Method: Microcolumn gel card was used to screen irregular blood group antibodies in pregnant women undergoing maternal examination in our hospital from January 2017 to August 2018 and analyzing the antibody specificity of positive screening specimens. Results: Of the7 381 pregnant women, 32 had irregular blood group antibodies detected,the positive rate was 0.434%. Among them, 10 cases were anti-M, 3 cases were anti-E, 8 cases were anti-Ec, 4 cases were anti-D, 4 cases were anti-Lea, 1 case was antiDia, 1 case was anti-Wra,1 case was cold antibody. The pregnant women who had irregular blood group antibodies detected all had more than one pregnancy history. Conclusions: The irregular blood group antibodies detection rate was0.434% in pregnant women taking maternal examination at our hospital;anti-M was the most frequent. The antibodies of Rh blood group system and MNS blood group system could lead to the occurrence of hemolysis disease in newborn infants.