阿司匹林与氯吡格雷对冠心病的治疗效果比较

Comparison of the effects of aspirin and clopidogrel on coronary heart disease

目的比较冠心病采取阿司匹林与氯吡格雷的治疗效果。方法选择2016年6月至2017年7月余姚市第三人民医院收治的冠心病患者186例为研究对象,采用随机数余数分组法分为对照组93例及观察组93例。两组均予以常规对症治疗,对照组使用阿司匹林,观察组予以氯吡格雷治疗。观察两组生化指标、心功能及不良事件发生情况。结果两组治疗前各项指标差异均无统计学意义(均P>0.05);治疗后,观察组血小板聚集率为(38.11±2.15)%,部分凝血酶活化时间为(48.21±3.50)s,均优于对照组(t=48.819、18.752,均P<0.05),两组凝血酶原活动度及凝血酶原时间差异无统计学意义(P>0.05);观察组心功能分级数据优于对照组,观察组心功能Ⅳ级、Ⅰ级概率分别为8.60%、38.71%,与对照组差异均有统计学意义(χ^2=5.243、6.541,均P<0.05);观察组不良事件发生率(1.08%)低于对照组(7.53%),差异有统计学意义(χ^2=4.072,P<0.05)。结论在冠心病治疗中,相比阿司匹林,氯吡格雷应用效果更佳,可显著改善患者凝血功能、心功能,且安全性较高,不良反应少。

Objective To compare the therapeutic effect of aspirin and clopidogrel on coronary heart disease.Methods From June 2016 to July 2017,186 patients with coronary heart disease in the Third People's Hospital of Yuyao were divided into control group and observation group according to different treatment methods,with 93 cases in each group.Both two groups were treated with routine symptomatic therapy,the control group was given aspirin and the observation group was given clopidogrel.Biochemical indicators,cardiac function and adverse events were observed.Results There were no statistically significant differences between the two groups before treatment(all P>0.05).The platelet aggregation rate and activation time of partial thrombin of the observation group were(38.11±2.15)%and(48.21±3.50)s,respectively,which were better than those of the control group(t=48.819,18.752,all P<0.05).There were no statistically significant differences in prothrombin activity and prothrombin time between the two groups(all P>0.05).The probability of gradeⅣand gradeⅠin the observation group was 8.60%and 38.71%,respectively,which was significantly different from those in the control group(χ^2=5.243,6.541,all P<0.05).The incidence rate of adverse events in the observation group(1.08%)was lower than that in the control group(7.53%),and the difference was statistically significant(χ^2=4.072,P<0.05).Conclusion Clopidogrel is more effective than aspirin in the treatment of coronary heart disease.It can significantly improve the coagulation function,cardiac function,and it is safe and with less adverse reactions.