银杏叶胶囊联合单硝酸异山梨酯治疗冠心病心绞痛的临床研究

Clinical study of Ginkgo biloba capsule combined with isosorbide mononitrate in treating angina pectoris of coronary heart disease

目的探索银杏叶胶囊联合单硝酸异山梨酯治疗冠心病心绞痛的临床效果。方法选取2017年4月22日至2018年4月22日舟山市中医院收治的冠心病心绞痛患者100例,采用奇偶数分组法分为两组各50例,对照组采用单硝酸异山梨酯治疗,观察组采用银杏叶胶囊联合单硝酸异山梨酯治疗。比较两组治疗前后左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室射血分数(LVEF)、心绞痛持续时间、心绞痛发作频率、总有效率、不良反应发生率、心绞痛缓解时间。结果观察组患者的LVEDD(48.41±2.23)mm、LVESD(30.89±1.12)mm、LVEF(56.55±5.87)%、总有效率96.00%、不良反应发生率4.00%、心绞痛持续时间(3.44±1.52)min/次、心绞痛发作频率(1.36±0.54)次/周、心绞痛缓解时间(3.12±0.56)min,均优于对照组患者的LVEDD(64.78±2.89)mm、LVESD(42.21±1.55)mm、LVEF(43.46±1.52)%、总有效率74.00%、不良反应发生率28.00%、心绞痛持续时间(5.68±1.66)min/次、心绞痛发作频率(2.68±1.47)次/周、心绞痛缓解时间(4.87±1.41)min(t=19.546、41.857、15.264,χ^2=9.490、10.714,t=7.037、5.960、8.156,均P<0.05)。结论对冠心病心绞痛患者实施银杏叶胶囊联合单硝酸异山梨酯治疗效果显著。

Objective To explore the clinical effect of Ginkgo biloba capsule combined with isosorbide mononitrate in the treatment of angina pectoris of coronary heart disease.Methods From April 22,2017 to April 22,2018,100 patients with coronary heart disease and angina pectoris admitted to Zhoushan Traditional Chinese Medicine Hospital were enrolled in the study.Fifty patients in the control group were treated with isosorbide mononitrate.Fifty patients in the observation group were treated with Ginkgo biloba capsules and isosorbide mononitrate.The left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),left ventricular ejection fraction(LVEF),duration of angina pectoris,frequency of angina attacks,total effective rate,incidence of adverse reactions,angina relief time were observed.Results The LVEDD,LVESD,LVEF,total effective rate,incidence rate of adverse reaction,duration of angina pectoris,angina pectoris frequency and angina pectoris remission time in the observation group were(48.41±2.23)mm,(30.89±1.12)mm,(56.55±5.87)%,96.00%,4.00%,(3.44±1.52)min/time,(1.36±0.54)times/week,(3.12±0.56)min,respectively,which were better than those in the control group[LVEDD(64.78±2.89)mm,LVESD(42.21±1.55)mm,LVEF(43.46±1.52)%,total effective rate(74.00%),incidence rate of adverse reactions(28.00%),duration of angina pectoris(5.68±1.66)min/time,frequency of angina pectoris(2.68±1.47)times/week,angina relief time(4.87±1.41)min](t=19.546,41.857,15.264,χ^2=9.490,10.714,t=7.037,5.960,8.156,all P<0.05).Conclusion Ginkgo biloba capsule combined with isosorbide mononitrate is effective in the treatment of patients with coronary heart disease and angina pectoris.