肾炎康复片联合氯沙坦对慢性肾小球肾炎患者细胞免疫功能、炎性因子和肾功能的影响

Effects of Shenyankangfu tablets combined with losartan on cellular immune function,inflammatory factors and renal function in patients with chronic glomerulonephritis

目的探讨肾炎康复片联合氯沙坦对慢性肾小球肾炎患者细胞免疫功能、炎性因子和肾功能的影响。方法选取2017年3月至2018年3月杭州市大江东医院收治的慢性肾小球肾炎患者94例,按照随机数字表法将患者分为观察组47例与对照组47例。对照组给予氯沙坦治疗,观察组在对照组基础上联合肾炎康复片治疗。两组疗程均为12周。比较两组治疗前后细胞免疫功能、炎性因子和肾功能变化及治疗疗效。结果观察组治疗后CD3^+(71.98±3.28)%、CD4^+(40.01±3.86)%和CD4^+/CD8^+(1.54±0.23),高于对照组的(64.32±4.01)%、(34.87±1.96)%和(1.23±0.16)(t=10.137、8.140、7.585,均P<0.05)。治疗后观察组白细胞介素2(3.18±0.59)μg/L,高于对照组的(2.37±0.71)μg/L,而白细胞介素6(227.42±12.41)ng/L和肿瘤坏死因子α(2.45±0.29)ng/L均低于对照组的(289.64±19.36)ng/L和(3.38±0.65)ng/L(t=6.015、18.549、8.958,均P<0.05)。观察组治疗后前血肌酐(123.49±8.97)μmol/L、尿蛋白(0.76±0.18)g/24h和尿素氮(6.71±0.5)mmol/L,低于对照组的(159.51±7.41)μmol/L、(1.28±0.23)g/24h和(7.91±0.47)mmol/L(t=21.224、12.206、11.136,均P<0.05)。观察组总有效率(93.62%)高于对照组(72.34%)(P<0.05)。结论肾炎康复片联合氯沙坦可改善慢性肾小球肾炎患者细胞免疫功能和肾功能,减轻炎性反应,疗效显著,值得临床借鉴。

Objective To investigate the effects of Shenyankangfu tablets combined with losartan on cellular immune function,inflammatory factors and renal function in patients with chronic glomerulonephritis.Methods From March 2017 to March 2018,94 patients with chronic glomerulonephritis admitted to Hangzhou Dajiangdong Hospital were randomly divided into observation group(47 cases)and control group(47 cases).The control group was treated with losartan,and the observation group was treated with Shenyankangfu tablets on the basis of the control group.The two groups were treated for 12 weeks.The changes of cellular immune function,inflammatory factors and renal function were compared between the two groups before and after treatment.Results After treatment,the levels of CD4^+(71.98±3.28)%,CD4^+(40.01±3.86)%and CD4^+/CD8^+(1.54±0.23)in the observation group were higher than those in the control group[(64.32±4.01)%,(34.87±1.96)%and(1.23±0.16)](t=10.137,8.140,7.585,all P<0.05).After treatment,the level of IL-2 in the observation group[(3.18±0.59)μg/L]was higher than that in the control group[(2.37±0.71)μg/L],while the levels of IL-6[(227.42±12.41)ng/L]and TNF-α[(2.45±0.29)ng/L]in the observation group were lower than those in the control group[(289.64±19.36)ng/L and(3.38±0.65)ng/L](t=6.015,18.549,8.958,all P<0.05).After treatment,the levels of Scr[(123.49±8.97)μmol/L],Upro[(0.76±0.18)g/24h]and BUN[(6.71±0.5)mmol/L]in the observation group were lower than those in the control group[(159.51±7.41)μmol/L,(1.28±0.23)g/24h,(7.91±0.47)mmol/L](t=21.224,12.206,11.136,all P<0.05).The total effective rate of the observation group(93.62%)was higher than that of the control group(72.34%)(P<0.05).Conclusion Shenyankangfu tablets combined with losartan can improve the cellular immune function and renal function in patients with chronic glomerulonephritis,and can reduce inflammatory reaction.The curative effect is remarkable,which is worthy of clinical reference.