辛伐他汀联合阿奇霉素治疗老年慢性阻塞性肺疾病合并肺动脉高压的效果

Effects of Simvastatin Combined with Azithromycin on Chronic Obstructive Pulmonary Disease with Pulmonary Hypertension in Older Patients

目的观察辛伐他汀联合阿奇霉素对老年慢性阻塞性肺疾病(COPD)合并肺动脉高压(PH)的治疗效果。方法选取无锡市人民医院2014年1月~2016年12月收治的老年COPD合并PH的患者80例,按随机数表法分为两组,对照组口服辛伐他汀,观察组在此基础上口服阿奇霉素肠溶片,比较两组治疗6个月后肺功能、血气分析指标及6min步行距离。结果治疗6个月后,与对照组比较,观察组肺功能指标的肺动脉平均压明显降低(P<0.05);用力肺活量(FVC)及第1秒用力呼气容积(FEV1)明显升高(P<0.05);动脉血氧分压(PaO2)及血氧饱和度(SaO2)明显升高(P<0.05);6min步行距离明显增加(P<0.05)。结论辛伐他汀联合阿奇霉素治疗老年COPD合并肺动脉高压能够降低肺动脉平均压,增强肺功能,疗效显著,值得临床上推广。

Objective To investigate the effects of simvastatin combined with azithromycin in the treatment of chronic obstructive pulmonary disease ( COPD) with pulmonary hypertension. Methods 80 older patients who suffered from COPD complicated with pulmonary hypertension between January 2014 and December 2016 were selected. The patients were randomly divided into the control group and the observation group. The control group received oral simvastatin. The observation group received oral simvastatin and azithromycin enteric - coated tablets. The pulmonary function, PaO2 and SaO2 and 6 minutes walking distance in the two groups were recorded after 6 months of treatment. Results After the treatment, compared with the control group, the mean pulmonary artery pressure in the observation group was decreased significantly ( P < 0. 05 ), while FVC and FEV, was increased significantly (P < 0. 05). PaO2, SaO2 and 6 minutes walking distance in the observation group were higher than those in the control group after treatment (P < 0. 05). Conclusion The combination of simvastatin and azithromycin may enhance the lung function and reduce the mean pulmonary artery pressure in patients with COPD complicated with pulmonary hypertension.