Ⅲa期非小细胞肺癌根治性放疗或联合化疗的疗效比较

Therapeutic Effects in Patients with Stage Ⅲa Non-small Cell Lung Cancer after Radical Radiotherapy or Radiotherapy Combined with Chemotherapy

目的探讨Ⅲa期非小细胞肺癌(NSCLC)根治性放疗或联合化疗的预后及影响因素。方法选取我院2014年9月~2017年2月收治的经病理学证实为Ⅲa期NSCLC且不能手术的患者112例,根据治疗方案分为两组。对照组39例,给予根治性放疗;观察组73例,给予根治性放疗联合化疗。对比两组的疗效及相关影响因素。结果观察组的完全缓解率及治疗总有效率显著高于对照组(P<0.05);观察组的1年、2年、5年生存率明显高于对照组(P<0.05),而死亡率则明显低于对照组(P<0.05)。N分级、放疗、化疗分别是影响实际生存率、无复发生存率及无转移生存率的独立预后因子。结论对Ⅲa期NSCLC患者给予根治性放疗联合同步化疗的生存率、治疗效果及预后优于单纯根治性放疗。

Objective To analyze the prognosis and influencing factors in patients with stage Ⅲ a non - small cell lung cancer ( NSCLC) after radical radiotherapy or radiotherapy combined with chemotherapy. Methods 112 patients with stage Ⅲa NSCLC in our hospital between September 2014 and February 2017 were divided into two groups. 39 cases in the control group were given radical radiotherapy. 73 cases in the observation group were given radical radiotherapy combined with chemotherapy. The therapeutic effects and influencing factors were compared between the two groups. Results The rate of complete remission ( CR) and the overall response rate in the observation group were significantly higher than those in the control group ( P <0. 05 ). One - year survival rate, two - year survival rate and five - year survival rate in the observation group were significantly higher than those in the control group ( P < 0. 05). One - year mortality rate, two - year mortality rate and five 一 year mortality rate in the observation group were lower than those in the control group ( P < 0. 05 ). N - grade, radiotherapy and themotherapy were independent prognostic factors affecting actual survival rate, recurrence - free survival rate and metastasis - free survival rate. Conclusion The survival, therapeutic effects and prognosis are better in stage Ⅲa NSCLC patients treated with radical radiotherapy combined with concurrent chemotherapy than those treated with radical radiotherapy alone.