外周血中性粒细胞计数与良性前列腺增生患者血清PSA水平的关系

Relationship between peripheral blood neutrophil count and serum PSA level in patients with benign prostatic hyperplasia

目的探讨外周血中性粒细胞计数(NC)和前列腺组织学炎症与良性前列腺增生(BPH)患者血清前列腺特异抗原(PSA)水平的关系。方法回顾性分析行经直肠超声引导下前列腺穿刺活检和病理诊断为BPH的530例患者的临床资料。采用一元线性回归模型和多元线性回归模型,分析外周血中性粒细胞计数、前列腺组织学炎症和其他临床参数与血清PSA水平的关系。根据外周血中性粒细胞计数的四分位间距将BPH患者分为四组(中性粒细胞计数<25%、25%≤中性粒细胞计数<50%、50%≤中性粒细胞计数<75%、中性粒细胞计数≥75%),比较各组伴和不伴组织学炎症患者间血清PSA水平的差异。结果一元线性回归模型显示,外周血中性粒细胞计数和组织学炎症均与血清PSA水平呈正相关(P<0.05);多元线性回归模型显示,外周血中性粒细胞计数是血清PSA水平的独立预测因子(P<0.05)。四组伴和不伴组织学炎症患者之间血清PSA水平均无统计学差异(P>0.05)。结论BPH患者外周血中性粒细胞计数是血清PSA水平的独立预测因子,炎症可能引起BPH患者血清PSA水平的升高。

Objective To explore the relationship between neutrophil count(NC)in peripheral blood,prostatic histologic inflammation and serum prostate specific antigen(PSA)level in the patients with benign prostatic hyperplasia(BPH).Methods The clinical data of 530 patients underwent transrectal ultrasonography-guided prostate biopsy and subsequently pathologically diagnosed as BPH were retrospectively analyzed.The association between serum PSA level and clinical parameters including NC in peripheral blood and prostatic histologic inflammation was assessed using univariate and multivariable linear regression models.The patients were divided into four groups according to the interquartile range of peripheral blood neutrophil count(NC<25%,25%≤NC<50%,50%≤NC<75%,NC≥75%).The difference of serum PSA level between the patients with and without histologic inflammation was analyzed.Results Although both NC in peripheral blood and prostatic histologic inflammation were positively correlated with serum PSA level in the patients with BPH in univariate linear regression models(P<0.05),only NC in peripheral blood was correlated with serum PSA level in multivariable model(P<0.05).There was no significant difference in serum PSA level between the patients with and without prostatic inflammation of the four groups(P>0.05).Conclusion NC in peripheral blood is an independent predictive factor of serum PSA level in the patients with BPH.Inflammation might cause the raise of serum PSA level in the patients with BPH.