雌马酚产生细菌及其雌马酚合成代谢机制

Research progress in equol-producing bacteria and their metabolism

大豆食品中通常富含染料木素和大豆苷元等异黄酮素,人和动物肠道中的某些细菌具有将异黄酮素代谢转化为S-雌马酚的能力。到目前为止,S-雌马酚被认为是一种具有潜在健康调节作用的化合物。啮齿类动物均具备产雌马酚的能力,但不同人群之间存在差异,产雌马酚细菌是否存在可能是造成这种差异的重要原因;不同产雌马酚细菌的代谢机制可能不同,并影响机体最终产雌马酚的能力。本文对已知的各种产雌马酚细菌及其细菌的雌马酚合成机制进行综述,以期为进一步了解雌马酚产生个体差异、雌马酚代谢转化效率、体外雌马酚的发酵生产,以及临床产雌马酚细菌的应用等提供理论参考。

Soybean contains high content of isoflavones such as genistein and daidzein, both can be converted to equol by intestinal microflora in human and animals. Equol may play an important role in human and animal health. Rodent species consistently produce high levels of equol, however, not all humans can produce equol. Equol-producing bacteria may be the key factors for this difference. Equol-producing bacteria may also have different equol-producing mechanism and capacity. In this paper, all equol-producing bacteria and their equol synthesis mechanism are reviewed, for further understanding the factors of equol-producing difference, the transformation of equol-producing ability, equol fermentation in vitro and applying to human clinical studies.