盆腔肿瘤放疗后骨盆不完全性骨折的研究现状

Current research progress on pelvic insufficiency fractures after radiotherapy for pelvic neoplasms

骨盆不完全性骨折(PIF)是盆腔肿瘤放疗后重要的并发症,常导致患者顽固性疼痛和活动受限且易被误诊为骨转移瘤而给予错误的治疗。MRI是其诊断和鉴别诊断的常用手段。预防PIF的理想方法是早期正确识别高危人群且必要时给予药物干预,放疗开始时患者的低骨密度状态是重要预测因素。合理选择盆腔淋巴引流区照射剂量并尽量降低骨盆剂量可能会降低放疗后PIF的发生。

Pelvic insufficiency fractures (PIF) is a vital complication after radiotherapy for pelvic neoplasms. It often leads to intractable pain and limited activity and is likely to be misdiagnosed as bone metastases and improperly treated. MRI is a common method for the diagnosis and differential diagnosis of PIF. The optimal approach to prevent PIF is to correctly identify the high-risk population and provide drug intervention when necessary. The low bone density state serves as a pivotal predictor at the beginning of radiotherapy. Reasonable selection of irradiation dose in pelvic lymphatic drainage area and minimizing the dose of pelvic bone probably reduce the incidence of PIF after radiotherapy.