摘要
脂氧素(lipoxins,LXs)是一种具有抗炎、调节免疫反应、促进细胞损伤修复的内源性脂质介质,被称为炎症反应的“刹车信号”。研究表明,LXs及阿司匹林诱生型脂氧素(aspirin-triggeredlipoxinA4,ATL)在调控炎症通路的同时,能通过多种途径促进小胶质细胞和巨噬细胞吞噬凋亡碎片、坏死细胞,发挥促炎症消退、稳定内环境的作用。文章综述相关文献,以了解LXs对吞噬功能作用的最新进展,其机制主要可分为4种:①改变细胞极性,重组细胞结构;②上调吞噬受体;③激活M2型吞噬细胞;④抑制吞噬细胞凋亡。小胶质细胞及其吞噬功能在多种脑相关疾病中发挥重要作用,研究LXs对吞噬功能的影响也许能为相关脑病的治疗提供思路。
Lipoxins (LXs) are endogenous lipid mediators that play a role on anti-inflammatory action, regulating immune response, and repairing damaged cells. It was also known as "the brake signal" of inflammatory response. Researches revealed that LXs and aspirin-triggered lipoxin A4 (ATL) promote the macrophage cells and microglia cell phagocytose cell debris and apoptotic cells by different ways while it regulates anti-inflammation effect and stabilize internal milieu. We reviewed the research progresses in the study of LXs and phagocytosis and summarized their roles as four mechanisms:① Changing cell polarity and rebuild cellular structure.② Up-regulation of specific scavenger receptors.③ Activating M2 phagocytes.④ Inhibition the apoptosis of phagocytes. Microglia and its phagocytosis function play vital roles in brain diseases, thus studying LXs may provide new therapeutic strategies.
作者
刘敏
宋丽敏
吴艳
尚游
Liu Min;Song Limin;Wu Yan;Shang You(Institute of Anesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China;Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China)
出处
《国际麻醉学与复苏杂志》
CAS
2019年第7期693-697,共5页
International Journal of Anesthesiology and Resuscitation
基金
国家自然科学基金(81471202).
关键词
脂氧素
炎症
吞噬作用
Lipoxin
Inflammatory
Phagocytosis
