小儿肠胃康颗粒辅助治疗小儿消化不良性腹泻52例临床观察

Clinical observation on Xiao’er Changweikang Keli (小儿肠胃康颗粒) in adjuvant treatment of 52 cases of infantile lientery

目的观察小儿肠胃康颗粒辅助治疗小儿消化不良性腹泻的临床疗效。方法选取2015年4月至2018年6月杭州市萧山区第二人民医院儿科收治的消化不良性腹泻患儿102例,按照随机数字表法分为治疗组52例和对照组50例。对照组予枯草杆菌二联活菌颗粒口服,治疗组在对照组治疗方法的基础上联合小儿肠胃康颗粒口服,2组均以3 d为1个疗程,连续治疗2个疗程后统计疗效。结果治疗组呕吐、腹痛、腹泻消失时间及大便颜色、性状恢复正常时间均明显短于对照组,2组比较,差异均有统计学意义(P<0.05)。治疗组总有效率为96.15%,对照组为76.00%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组血浆胃动素(MTL)、胃泌素(GAS)水平比较,差异无统计学意义(P>0.05),具有可比性。治疗后,2组血浆MTL、GAS水平均较同组治疗前明显降低(P<0.05),且治疗组降低更显著(P<0.05)。结论小儿肠胃康颗粒辅助治疗小儿消化不良性腹泻,能显著缓解患儿的临床症状,改善胃肠功能,疗效显著,且药物安全性高,值得临床推广应用。

Objective To observe the clinical efficacy of Xiao’er Changweikang Keli (小儿肠胃康颗粒) in adjuvant treatment of infantile lientery.Methods Totally 102 cases of infantile lientery admitted into department of pediatrics in Hangzhou Municipal Xiaoshan District the Second People’s Hospital from April 2015 to June 2018 were divided into treatment group with 52 cases and control group with 50 cases according to random number table method.The control group was given oral administration of combined bacillus subtilis and enterococcus faecium granules with multivitamines,live,and the treatment group was combined with oral administration of Xiao’er Changweikang Keli on the basis of the therapeutic method of the control group.The 2 groups were treated for 3 days as 1 course of treatment,and the curative effects were kept statistically after 2 consecutive courses of treatment.Results The disappearance time of vomiting,abdominal pain,diarrhea,and recovery time of feces color and character of the treatment group were significantly shorter than those of the control group,and the difference was statistically significant between the two groups (P<0.05).The total effective rate of the treatment group was 96.15%,that of the control group was 76. 00%,and the difference was statistically significant between the two groups (P < 0. 05). Before treatment,there was no statistically significant difference in the levels of plasma motilin (MTL) and gastrin (GAS)between the two groups (P>0.05),and they were comparable.After treatment,the levels of plasma MTL and GAS of the two groups significantly decreased compared with the same group before treatment (P < 0. 05),moreover,the treatment group decreased more significantly (P<0.05).Conclusion Xiao’er Changweikang Keli (小儿肠胃康颗粒) in adjuvant treatment of infantile lientery can markedly relieve the clinical symptoms of children,and improve the gastrointestinal function with significant curative effect and high drug safety,which is worthy of clinical promotion and application.