口腔微生物群与牙周病

Oral microbiota and periodontal disease

口腔微生物群作为人体微生物群的重要组成部分,种类繁多、组成复杂,其组成和比例与各类口腔疾病密切相关。牙周炎是一种多微生物的复合感染,它由口腔内微生物群中潜在的致病微生物丰度增加引起,这些微生物通过介导炎症反应及调节口腔微生物群的基础营养环境而致病。本文综述了近年来口腔微生物群与牙周疾病之间的关系及相关影响因素,并分析了目前牙周病微生物群研究的挑战与瓶颈,为将微生物群作为预防、诊断和治疗牙周相关疾病的生物标记物并进一步应用于临床提供理论基础。

As an important part of microbial community of human body,oral microflora is composed of a wide variety of microorganisms with different proportions which are closely related to all kinds of oral diseases.Periodontitis is a multiple infection with multiple microorganisms.It is caused by the increase in abundance of potential pathogenic microorganisms in oral microflora,and these microorganisms are responsible for mediating inflammatory reactions and regulating nutritional environment of oral microflora.This article will clarify the relationship between oral microflora and periodontal diseases,explore the related influencing factors,and analyze the challenges and bottlenecks in the study on periodontal microflora,with the purpose of providing further foundation to use microbial community as a biomarker for the prevention,diagnosis and treatment of periodontal diseases.