微生态调节剂在肿瘤治疗中的应用

Application of microbiome modulator in tumor treatment

肿瘤的治疗方法包括手术治疗、化学治疗、放射治疗、靶向治疗、免疫治疗等。但是药物副反应、疾病耐药和肿瘤复发是目前面临的困难。近年来,微生物与肿瘤相互作用的研究成为热点。越来越多的研究表明,可以通过调节微生态来对抗肿瘤,提高肿瘤治疗的疗效,减小治疗的副作用,从而进一步提高肿瘤患者的生活质量。本文就微生态调节剂应用于治疗肿瘤作一综述,我们回顾了有关益生菌在肿瘤治疗中的应用,此外,我们讨论益生菌、益生元、合生元、微生物代谢物和抗生素与化疗及免疫治疗共同应用的益处。

The treatment methods of tumors include surgery,chemotherapy,radiotherapy,targeted therapy,immunotherapy and so on.However,side effects of drugs,drug resistance,and tumor recurrence are currently the challenges we are facing.In recent years,the research on the interaction between microorganisms and tumors has become a hot topic.More and more studies have shown that regulation of microbiome can fight tumors,improve the curative effect,reduce the side effects of treatment and then improve the quality of life(QOL)of tumor patients.This article reviews the application of microbiome modulators in the treatment of tumors.We reviewed the application of probiotics in tumor treatment,and discussed the benefits of probiotics,prebiotics,synbiotics,microbial metabolites and antibiotics combined with chemotherapy and immunotherapy.