中国遗传改变小鼠研发与市场在近20年的发展与变化

Development and change of research and market in the field of genetically modified mouse in China in recent 20 years

遗传改变小鼠是基因组经过"修饰"或"改造"的实验用小鼠,作为实验动物的重要组成在中国近20年里得到了飞速发展,被先后应用于生命科学与医学的基础研究、抗体药物评价与抗体药物研发等转化应用项目中。介绍了近20年中国遗传改变小鼠领域的国家投入、机构建设、市场发展、学术交流、工作重点及成果积累等方面的发展与变化。

Experimental zoology in China began to develop in the early 1980 s. With the rapid development of China’s reform and opening up, China’s experimental animal science and industry have entered the regular development stage. Genetically modified mice, as an important part of experimental animals, have developed rapidly in China in the past two decades, and have been successively applied in life science and basic medical research, antibody drug evaluation, antibody drug research development and other transformation applications.This review is to expound the development situation of genetically modified mice through the classified statistics and research methods on the six aspects including national investment, institution construction, market development, academic exchange, work focus and achievement accumulation. Finally, this review summarizes the standard establishment process and research development of genetically modified mice in China in the past two decades.