高州市就诊女性HPV感染的流行病学特征分析

Epidemiological characteristics of HPV infection in females in Gaozhou city

目的探讨高州市女性HPV感染的流行病学特征,为当地预防HPV感染提供参考。方法选取2016年9月-2018年3月期间广东省高州市人民医院妇科、门诊、两癌筛查,以及体检科收治的1500例患者,采用表面等离子共振技术进行HPV定量分型检测,分析高州市就诊女性HPV感染的流行病学特征。结果①1500例女性中,HPV阳性检出率15.33%(230/1500)。检出HPV亚型感染260例次,其中高危亚型237例次(91.15%)、低危亚型23例次(8.85%)。高危亚型中以HPV 16占比最高(23.08%),HPV 58(15.77%)和HPV 52(12.69%)占比次之;低危亚型中以HPV6占比最高(5.77%)。②不同年龄段中,<50年龄段中HPV检出率最高(31.54%),<40(25.00%)和<60(18.46%)年龄段次之。③HPV感染模式以二重感染为主,一重感染次之,三重感染及以上最低;不同年龄段之间感染模式比较差异无统计学意义(P>0.05)。结论高州市1500例就诊女性中,HPV阳性检出率为15.33%,感染以高危亚型和二重感染率为主,感染年龄以40~60岁最高,该年龄段女性需提高警惕。

Objective To investigate the epidemiological characteristics of HPV infection among women in Gaozhou,and to provide reference for local prevention of HPV infection. Methods A total of 1500 people admitted to the gynaecology,outpatient,two cancer screening and physical examination departments in our hospital from September 2016 to March 2018 were selected as the subjects. Tthe surface plasmon resonance technique was used for HPV quantitative typing to analyze the epidemiological characteristics of HPV infection amongwomen in Gaozhou. Results ① Among 1500 women,the HPV positive rate was 15. 33%( 230/1500). 260 cases of HPV subtype infection were detected,including 237 cases of high-risk subtypes( 91. 15%) and 23 cases of low-risk subtypes( 8. 85%). Among the high-risk subtypes,HPV 16 accounted for the highest proportion( 23. 08%),following HPV 58( 15. 77%)and HPV 52( 12. 69%). HPV6 accounted for the highest proportion( 5. 77%) among the low-risk subtyoes.② Among different age groups,HPV detection rate was the highest( 31. 54%) in < 50 age group,following < 40( 25. 00%) and < 60( 18. 46%).③HPV infection pattern was dominated by double infection,followed by one infection,and triple infection was the lowest. There was no significant difference in infection patterns between different age groups( P > 0. 05). Conclusion The positive detection rate of HPV among women in Gaozhou is 15. 33%. The infection is mainly high-risk subtype and double infection rate. The highest age of infection is 40-60 years old. The women in this age group need to be paid more attention to.