医用硅橡胶导管的表面改性及其亲水性和抗菌性研究

Study on Surface Modification, Hydrophilicity and Antibacterial Property of Medical Silicone Rubber Catheter

对硅橡胶导管进行表面改性,制备具有亲水和抗菌功能的医用硅橡胶导管,并对其性能进行表征。结果表明:与未改性导管相比,改性导管的摩擦系数减小90%以上,亲水性明显改善;水浸泡7d后改性导管仍具有较好的润滑性,且涂层与导管表面的粘合性较好;改性导管对金黄色葡萄球菌具有良好且持久的抗菌性,能满足临床应用要求,具有良好的应用前景。

The medical silicone rubber catheter with good hydrophilicity and antibacterial property was prepared by surface modification of silicone rubber catheter,and its properties were tested. The results showed that,compared with the unmodified catheter,the friction coefficient of modified catheter was reduced by 90% or more,and the hydrophilicity was significantly improved. After being soaked in water for 7 days,the modified catheter still possessed good surface lubricity,and the adhesion between the modification coating layer and the catheter surface was good. The modified catheter had good and lasting antibacterial effect on staphylococcus aureus,which met the requirements of clinical application and had a great application prospect.