血清IL-17和IL-23水平与梅毒病期的相关性

The relationship of the levels of IL-17 and IL-23 in serum with syphilis

目的:明确梅毒病期与IL-17和IL-23表达的相关性。方法:采用ELISA法检测收集到的早期梅毒和晚期梅毒患者血清中的IL-17和IL-23水平。结果:共检测18例早期梅毒,18例晚期梅毒及12例正常对照血清。早期梅毒组和晚期梅毒组IL-17分别为(12.723±8.547)ng/L和(18.757±10.607)ng/L,差异无统计学意义(P>0.05);IL-23水平分别为(9.049±7.301)ng/L和(13.603±7.694)ng/L,差异无统计学意义(P>0.05)。早、晚期梅毒患者IL-17和IL-23水平均高于对照组患者[(5.766±2.153)ng/L和(2.756±1.843)ng/L](均P<0.05)。结论:梅毒患者血清中的IL-17和IL-23表达水平与病期无相关性。

Objective:To study the correlation between the level of IL-17 and IL-23 and the different courses of syphilis.Methods:The serum levels of IL-17 and IL-23 in the patients with early syphilis and late syphilis were detected by ELISA.Results:The sera of eighteen patients with early syphilis,18 patients with late syphilis and 12 healthy controls were collected.The level of IL-17 in the patients with early syphilis and patients with late syphilis were(12.723±8.547)ng/L,(18.757±10.607)ng/L,respectively,with no significant difference(P>0.05);The level of IL-23 were(9.049±7.301)ng/L,(13.603±7.694)ng/L,respectively,with no significant difference(P>0.05).The level of IL-17 and IL-23 in the early syphilis patients and late syphilis patients were higher than those in healthy controls[(5.766±2.153)ng/L,(2.756±1.843)ng/L,respectively](P s<0.05).Conclusion:There is no correlation between the level of IL-17 and IL-23 and the courses of TP syphilis.