短链脂肪酸参与多种疾病发病机制的研究进展

Progress of short chain fatty acids in the pathogenesis of various diseases

肠道菌群可被视为人体的一种“新器官”,它能产生多种物质,从而对机体造成多方面的影响。短链脂肪酸(short chain fatty acids, SCFAs)是肠道菌群产生的一类信号分子,在许多疾病的发生、发展中起重要作用。本文主要讲述SCFAs与各种疾病的关系,通过分析SCFAs在肠道疾病、肥胖相关疾病、自闭症、气道炎症性疾病、高血压等疾病中的作用机制,为相应疾病的病因和治疗提供新的思路,从而更好地实现对相关疾病的精准治疗与个体化治疗。

Gut microbiota can be regarded as a “new organ” of the human body, which can produce various substances and have many effects on the body. Short chain fatty acids (SCFAs), which are signaling molecules produced by gut microbiota, play an important role in the occurrence and development of many diseases. This article mainly discussed the relationship between SCFAs and various diseases, such as intestinal diseases, obesity-related diseases, autism, airway inflammatory diseases, and high blood pressure. New ideas can be provided for the etiology and treatment of corresponding diseases, and precise and individualized treatment of related diseases will be realized better by analyzing the mechanism.